Trittiko analogue is cheaper. Trittiko antidepressant analogues: a review of drugs with similar effects

The history of my illness goes deep into my childhood, but it manifested itself most of all six years ago, since then I have been suffering from depression, GAD with pan-attacks and phobias, occasional insomnia and nightmares due to PTSD (and a number of its symptoms). But that's not the point. The point is, after a bunch of... The history of my illness goes deep into my childhood, but it manifested itself most of all six years ago, since then I have been suffering from depression, GAD with pan-attacks and phobias, occasional insomnia and nightmares due to PTSD (and a number of its symptoms).
But that's not the point. The bottom line is that, after a bunch of drugs prescribed to me, this one, so to speak, satisfied all my requirements. Depression is gradually fading away, working capacity has increased, a desire to create and live in general appeared, apathy subsided, I became calm, like a tank, for the first time in a long time I was finally able to sleep well with the lights off (yes, that was my main phobia, how would it didn't sound). Side effects came to light in the form that I took a beta-blocker for the prevention of pan. attacks, and I finally removed it, since Trittiko already has the property of an alpha-adrenergic blocker. Be careful with this! Low blood pressure, weakness, dizziness, palpitations and general discomfort in the region of the heart are clear reasons for reducing the dosage of an adrenergic blocker of any kind, or even stopping it altogether. Also be careful when using sedative drugs together, especially from a number of benzodiazepines (phenozepam, alprozalam, etc.). In principle, they are relatively easy to get off, thanks again to Trittiko.

Advantages- Fast action;
- It is effective both in the treatment of depression and in anxiety disorders, or even anxiety-depressive r-ve;
- Good and as a sleeping pill;
- Due to its adrenoceptor blocking effect, it is possible to reduce the severity of symptoms of pan-disorder

disadvantages- Not a very pleasant side effect in the form of menstrual irregularities, but I learned to live with it, because. I was told that with the long use of such drugs, this is also possible;
- Be careful when taking adrenoblockers at the same time.

I started taking 1/3 tablet, now it's full. Gradually increased the dose despite allergic side effects, tk. the drug itself improved the psychological state. But now I'm thinking of stopping taking it: constant inflammation of the eyes, itching on the face, dry mouth in the morning, but the most unpleasant thing is that an incomprehensible cough has been added. It's a pity.

A very good drug, if it doesn’t cause side effects in you, anxiety is forgotten, fears_ just gradually come to life! as always, oh, nothing will happen. But at night I got up, I didn’t have time to reach ... It darkened in my eyes, grabbed a can of coffee. So ... A very good drug, if it doesn’t cause side effects in you, anxiety is forgotten, fears_ just gradually come to life! as always, ah, nothing will happen. But at night I got up, did not have time to reach ... It darkened in my eyes, grabbed a can of coffee. it’s back to normal - the pressure drops so quickly! Now I started with amitroptyline, it’s still better than others. I’m thinking of switching to tritico - I don’t know the doctor’s reaction.

I am 30 years old, since childhood I have been tormented by a constant feeling of anxiety, but still, that sometimes it’s impossible to do anything and the presence of fear, and depression came from this hopelessness, I tried many antidepressants, tranquilizers, but then the doctor prescribed me trittiko I drink 4 days 50mg and the effect is amazing, I feel... I am 30 years old, since childhood I have been tormented by a constant feeling of anxiety, but still, that sometimes it’s impossible to do anything and the presence of fear, and depression came from this hopelessness, I tried many antidepressants, tranquilizers, but then the doctor prescribed me trittiko I drink 4 days 50 mg and the effect is amazing, I feel like a man again, I will continue to drink it as much as I need and it is not addictive, as it is written in the instructions, there was not a single side effect, except for dry mouth, then I plan to do an MRI of the brain and undergo psychotherapy, to get to the bottom of why I suffer from anxiety since childhood, I put 5+ trittiko!!

Trittiko is a dangerous drug, and even more so if you drink it without a doctor's prescription. We've all become so smart. We ourselves, children are treated and treated on the Internet, on forums, according to reviews. This can be crazy. Look for advice on the forums. I had a bitter experience with the use of this Trittiko, climbed such ... Trittiko is a dangerous drug, and even more so if you drink it without a doctor's prescription. We've all become so smart. We ourselves, children are treated and treated on the Internet, on forums, according to reviews. This can be crazy. Look for advice on the forums.
I had a bitter experience on the use of this Trittiko, got such side effects that you would not wish on the enemy. Although I drank according to the doctor's prescription. I took half a pill and it was still bad.

Trittiko I took last winter. I had a misfortune and a terrible depression began - I didn’t eat anything, while I smoked and drank coffee, I lost 5 kg in 2 weeks, I hardly slept at night, later I started having stomach pains, headache, nausea, black circles under my eyes . All in all... Trittiko I took last winter. I had a misfortune and a terrible depression began - I didn’t eat anything, while I smoked and drank coffee, I lost 5 kg in 2 weeks, I hardly slept at night, later I started having stomach pains, headache, nausea, black circles under my eyes . In general, bad condition. Mom sounded the alarm, at first she persuaded, then she tried to force at least something to eat or go for a walk, I didn’t even go outside, I lay in bed all the time and cried. Then she told me how she gave me Trittiko. She dissolved the pills for me in water. I followed the instructions strictly according to the instructions, and on the 5th day I noticed that the mood began to appear and somehow I wanted to eat. And my mother told me that she gave me this Trittiko. After using it, I came to life, it really helps.

In this article, you can read the instructions for using the drug Trittiko. Reviews of site visitors - consumers of this antidepressant medication, as well as opinions of specialist doctors on the use of Trittiko in their practice are presented. A big request to actively add your reviews about the drug: did the medicine help or not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Trittico analogues in the presence of existing structural analogues. Use to treat depression, anxiety, and phobias in adults, children, and pregnancy and lactation. The composition and interaction of the drug with alcohol.

Trittiko- an antidepressant. Trazodone (the active ingredient of Trittico), being a derivative of triazolopyridine, has a predominantly antidepressant effect, with some sedative and anxiolytic effects. Trazodone has no effect on MAO, which distinguishes it from MAO inhibitors, tricyclic antidepressants.

The mechanism of action of trazodone is associated with the high affinity of the drug for certain subtypes of serotonin receptors, with which trazodone enters into an antagonistic or agonistic interaction, depending on the subtype, as well as with the specific ability to cause inhibition of serotonin reuptake.

Quickly affects mental (affective tension, irritability, fear, insomnia) and somatic symptoms of anxiety (palpitations, headache, muscle pain, frequent urination, sweating, hyperventilation).

Trittiko is effective in sleep disorders in patients with depression, increases the depth and duration of sleep, restores its physiological structure and quality.

Trittiko stabilizes the emotional state, improves mood, reduces the pathological craving for alcohol in patients suffering from chronic alcoholism during the period of alcohol withdrawal syndrome, also in remission. In withdrawal symptoms in patients suffering from dependence on benzodiazepine derivatives, trazodone is effective in the treatment of anxiety-depressive conditions and sleep disorders. During remission, benzodiazepines can be completely replaced by trazodone.

Helps restore libido and potency in both depressed and non-depressed patients.

The drug is not addictive. The neutral uptake of norepinephrine and dopamine is little affected.

Does not affect body weight.

Composition

Trazodone hydrochloride + excipients.

Pharmacokinetics

Absorption of the drug from the gastrointestinal tract after oral administration is high. Taking trazodone during or immediately after a meal slows down the rate of absorption. Plasma protein binding - 89-95%. Penetrates through histohematic barriers, as well as into tissues and fluids (bile, saliva, breast milk). Trazodone is metabolized in the liver, the active metabolite is 1-m-chlorophenylpiperazine. Most of the metabolites are excreted by the kidneys - about 75%, and excretion is completely completed 98 hours after ingestion; about 20% is administered with bile.

Indications

• anxiety-depressive states of endogenous nature (including involutional depressions);
• psychogenic depressions (including reactive and neurotic depressions);
• anxiety-depressive states against the background of organic diseases of the central nervous system (dementia, Alzheimer's disease, atherosclerosis of cerebral vessels);
• depressive states with prolonged pain syndrome;
• alcoholic depression;
• benzodiazepine dependence;
• libido and potency disorders (impotence), incl. in depressive states.

Release forms

75 mg and 150 mg controlled release tablets (long-acting).

Instructions for use and regimen

The drug is taken orally 30 minutes before a meal or 2-4 hours after a meal. The prescribed dose of the tablet should be taken whole, without chewing and drinking plenty of water.

Adults are prescribed in an initial dose of 100 mg 1 time per day after meals at bedtime. On the 4th day, you can increase the dose to 150 mg. In the future, in order to achieve the optimal therapeutic effect, the dose is increased by 50 mg per day every 3-4 days until the optimal dose is reached. A daily dose of more than 150 mg should be divided into 2 doses, with a smaller dose taken after dinner, and the main one at bedtime.

The maximum daily dose for outpatients is 450 mg.

The maximum daily dose for inpatients is 600 mg.

In the treatment of impotence, in the case of monotherapy with the drug, the recommended daily dose is more than 200 mg, with combined therapy - 50 mg.

In the treatment of benzodiazepine dependence, the recommended treatment regimen is based on a gradual, sometimes over several months, dose reduction of the benzodiazepine. Each time, reducing the dose of benzodiazepine by 1/4 or 1/2 tablets, add 50 mg of trazodone at the same time. This ratio is left unchanged for 3 weeks, then proceed to a further gradual reduction in the dose of benzodiazepines up to their complete abolition. Thereafter, reduce the daily dose of trazodone by 50 mg every 3 weeks.

Children aged 6-18 years: initial daily dose of 1.5-2 mg / kg per day, divided into several doses. If necessary, the dose is gradually increased to 6 mg / kg per day with an interval of 3-4 days.

Side effect

• increased fatigue;
• drowsiness;
• excitation;
• headache;
• dizziness;
• weakness;
• myalgia;
• discoordination;
• paresthesia;
• disorientation;
• tremor;
• decrease in blood pressure;
• orthostatic hypotension (especially in persons with vasomotor lability) due to the adrenolytic effect of the drug;
• arrhythmia;
• conduction disorder;
• bradycardia;
• leukopenia and neutropenia (usually minor);
• dryness and bitterness in the mouth;
• nausea, vomiting;
• diarrhea;
• loss of appetite;
• allergic reactions;
• eye irritation;
• priapism (patients who experience this side effect should immediately stop taking the drug and consult a doctor).

Contraindications

• pregnancy;
• lactation period;
• children's age up to 6 years;
• hypersensitivity to the components of the drug.

Use during pregnancy and lactation

The drug is contraindicated for use during pregnancy and lactation (breastfeeding).

Use in children

Contraindicated in children under 6 years of age. With caution, the drug should be prescribed to patients under the age of 18 years.

Use in elderly patients

For elderly and debilitated patients, the initial dose is up to 100 mg per day in divided doses or 1 time per day at bedtime. The dose may be increased under the supervision of a physician, depending on the effectiveness and tolerability of the drug. Usually no dose exceeding 300 mg per day is required.

special instructions

Since the drug has some adrenolytic activity, it is possible to develop bradycardia and lower blood pressure. Therefore, the drug should be used with caution in patients with impaired cardiac conduction, AV blockade of varying severity, patients with recent myocardial infarction.

When using Trittiko, a slight decrease in the number of leukocytes is possible, which does not require specific treatment, except in cases of severe leukopenia. Therefore, during the period of treatment, it is recommended to conduct studies of peripheral blood, especially in the presence of pain in the throat when swallowing and the appearance of fever.

The drug does not have an anticholinergic effect, therefore, it can be prescribed to elderly patients suffering from prostatic hypertrophy, angle-closure glaucoma, and cognitive impairment.

The drug is dispensed by prescription.

With the appearance of prolonged and inadequate erections, the patient should consult a doctor.

During the treatment period, the patient should refrain from drinking alcohol.

Influence on the ability to drive vehicles and control mechanisms

Since the drug has anxiolytic and sedative activity, it is possible to reduce the ability to concentrate and the speed of psychomotor reactions. During treatment, the patient should avoid engaging in potentially hazardous activities, incl. driving vehicles and operating mechanisms.

drug interaction

Trittico may enhance the effect of some antihypertensive drugs and usually requires a reduction in their doses.

Simultaneous administration with drugs that depress the central nervous system (including clonidine, methyldopa) enhances the effect of the latter.

Antihistamines and drugs with anticholinergic activity enhance the anticholinergic effect of trazodone.

Trazodone enhances and prolongs the sedative and anticholinergic effects of tricyclic antidepressants, haloperidol, loxapine, maprotiline, phenothiazine, pimozide, and thioxanthene.

MAO inhibitors increase the risk of side effects of trazodone.

When used together, it increases the concentration of digoxin and phenytoin in the blood plasma.

Trittiko's analogues

Structural analogues for the active substance:

• Azona.

Analogues by pharmacological group (antidepressants):

• Agomelatine;
• Adepress;
• Azaphen;
• Amizol;
• Amixid;
• Amirol;
• Amitriptyline;
• Anafranil;
• Asentra;
• Aurorix;
• Valdoxan;
• Venlaxor;
• Venlafaxine;
• Wenceworth;
• Heptor;
• Heptral;
• Deprenon;
• Deprim;
• doxepin;
• duloxetine;
• Zoloft;
• Ixel;
• Clomipramine;
• Coaxil;
• Lerivon;
• Maprotiline;
• Mirtazapine;
• Mirtazonal;
• Negrustin;
• Neuroplant;
• Oprah;
• Paxil;
• paroxetine;
• pyrazidol;
• Pleased;
• Prozac;
• Profluzak;
• Rexetin;
• Seralyn;
• sertraline hydrochloride;
• Stimuloton;
• Tryptisol;
• Fevarin;
• Fluxonil;
• fluoxetine;
• Cipralex;
• citalopram;
• Elivel;
• Escitalopram;
• Efevelon;
• Efevelon retard.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.

Diseases of the nervous system are common today. They are accompanied by depression, stress, insomnia and other unpleasant symptoms. To restore the functioning of the nervous system, there are many drugs, including Trittiko. Reviews of patients note that the medicine works effectively, normalizes sleep, and calms.

The composition of the drug

The drug "Trittiko" (patient reviews pay attention to its seriousness and are not advised to take the drug without consulting a doctor) is produced in the form of tablets that are packaged in a blister of 10 pieces. The package may contain two or six blisters, as well as detailed instructions for using the medication.

One pill contains about 150 mg of trazodone hydrochloride. The auxiliary components of the drug include carnauba wax, sucrose, magnesium stearate and povidone.

Pharmacology

It belongs to the group of long-acting antidepressants, the drug "Trittiko" (patient reviews indicate side effects that may develop with prolonged use of tablets). The drug is a derivative of triazolopyridine. It is characterized by anxiolytic, antidepressant and sedative properties.

Tablets remove the symptoms of anxiety, which has both a somatic and psychological origin. First of all, it is a feeling of fear, irritability, nervousness, pain in the muscles and head, sweating, insomnia and other symptoms. The medication normalizes the emotional state. Reduces craving for bad and harmful habits such as alcohol.

"Trittico" can be used in patients with withdrawal syndrome with dependence on benzodiazepines. The tool removes the state of anxiety and depression. Improves the quality of sleep. Tablets have a positive effect on libido, potency. The medicine does not develop addiction and does not affect weight gain.

Indications and contraindications

The main indications for the use of the drug "Trittiko" (reviews of patients believe that the drug alleviates hangover syndromes) are depressive and anxiety states of various genesis. Doctors recommend this remedy for benzodiazepine dependence, alcohol syndrome, libido disorders, and also for impotence.

Despite the pronounced effectiveness, the drug is not taken in case of hypersensitivity to this drug and the substances that make up its composition. It is forbidden to drink these pills to women during pregnancy and while breastfeeding. You can not drink the medication if there is intoxication of the body. Do not prescribe tablets to children whose age has not reached the age of six. A contraindication to taking the medication is a lack of sucrase / isomaltase. Do not drink pills with fructose intolerance, as well as with such a diagnosis as glucose-galactose malabsorption.

Tablets "Trittiko": instructions for use

Reviews indicate the need to study the instructions for the drug, since if used incorrectly, it can cause negative phenomena. According to the instructions, treatment begins with a daily dosage of 100 mg. From 1 to 3 days, the drug is taken once, at night. From the fourth day, if necessary, the dose is increased to 150 mg. In order to obtain the desired therapeutic effect, the dosage is increased gradually, once every 3-4 days. The daily rate of more than 150 mg is divided into two doses. A smaller dose is drunk at lunchtime, and the main amount of medication is taken before going to bed.

If the patient is being treated on an outpatient basis, then the daily dosage should not exceed 450 mg (3 tablets), for patients in the hospital, the maximum dose is 600 mg (4 tablets).

The drug is given to children from 6 to 18 years. Here, the daily dosage is calculated based on 1.5-2 mg / kg of the child's weight. The daily volume is divided into 2-3 doses. To achieve a therapeutic effect, it is allowed to increase the dose to 6 mg / kg. Increase the dose gradually, once every 3-4 days.

Elderly persons begin treatment with 100 mg. If the patient tolerates the drug well, then the daily rate is increased to 300 mg / day. To restore libido, the daily dose is 50 mg. With impotence, the dosage can reach up to 200 mg or more, and in complex therapy - 50 mg.

Benzodiazepine addiction is treated according to a special scheme. First, reduce the intake of benzodiazepines by ¼ or ½ tablets. At the same time, the drug "Trittico" is added. Dose changes are carried out once every three weeks, until the complete abolition of benzodiazepines. When only Trittiko tablets remain in treatment, they begin to reduce the dosage of this drug once every three weeks. Tablets are drunk whole. They cannot be chewed. Take the drug half an hour before eating or 2-4 hours after eating.

Overdose and side effects

The medicine "Trittiko" (reviews of doctors and patients note that the drug has a strong hypnotic effect) requires strict adherence to the dosage, otherwise an overdose may occur. As a rule, this is a gag reflex, drowsiness, nausea, dizziness. In especially severe cases, tachycardia, cramps in the limbs, hypotension, disruption of the respiratory and cardiac apparatus, hyponatremia may appear. All of the above symptoms appear in a person during the day.

The drug "Trittiko" can also cause negative effects, such as agranulocytosis, leukopenia, anemia, eosinophilia and thrombocytopenia. Patients complained of allergic reactions. Some experienced mental disorders, which manifested themselves in the form of phobias, confusion, fear, suicidal behavior, hallucinations.

In the treatment of this medication, especially at high doses, there were epileptic seizures, headache and dizziness. There was drowsiness. There was a tremor, amnesia, taste preferences often changed. People during therapy were worried about tachycardia, increased heart rate, bradycardia, a decrease and increase in blood pressure. There were ventricular extrasystoles. There was a prolongation of the QT interval. In some cases, patients lost consciousness.

Other side effects included nausea, abdominal pain, vomiting, diarrhea, dry mouth, and excessive salivation. There was a rash on the skin, itching, sweating.

special instructions

Patients with suicidal thoughts should be under medical supervision. This condition can last until a pronounced remission and most often manifests itself at the initial stage of recovery. Persons under the age of 24 are especially susceptible to suicide.

The adrenoblocking property of the drug can cause a sharp decrease or increase in blood pressure. Because of this, people with QT prolongation should be especially careful when treated with Trittiko. This applies to patients who have had a heart attack and suffering from atrioventricular blockade.

If a patient has a manic-depressive psychosis during treatment, then therapy should be discontinued. People with epilepsy should take the drug carefully, without drastic dose adjustments.

Tablets give a good result in insomnia caused by depression. In this case, they lengthen sleep, make it deeper, restore it. The drug does not affect the patient's weight and is not addictive.

"Trittiko": analogues

So, your doctor has just prescribed you Trittiko.

Pain became a constant companion of many people. It interferes with normal life. For example, 21% of Austrians suffer from chronic pain. On average, it takes 7 years from the onset of pain to the appointment of adequate treatment.

Pain reduces physical activity and interferes with full communication. It affects sleep, mood, well-being. Most of all, it is sleep disorders that reduce the quality of life.

Dream lies on the border of the psyche and somatics (soma - body, Greek). Adequate sleep is very important for restoring strength - physical and mental.

Why are antidepressants prescribed for chronic pain?

Many people ask themselves the question, “Why should I take antidepressants if I am in pain but not depressed?”

The effect of pain is not limited to sensory (physical) sensations. Pain directly or indirectly affects the well-being of a person as a whole, changes his mood. The sensory component (feeling of pain) is inseparable from its influence on the emotional sphere.

Pain affects both behavior and well-being.

Medical science knows that antidepressants not only fight depression, anxiety, but also reduce pain. Therefore, antidepressants are included in the recommendations for the treatment of chronic pain.

Antidepressants interfere with the conduction of pain impulses in the spinal cord and brain and can suppress the foci of circulation of pain impulses. Antidepressants with a hypnotic effect, such as Trittiko, additionally eliminate sleep disturbances.

The effect of antidepressants in chronic pain does not occur immediately. On average, pain decreases after a few weeks from the start of taking the drug .. Whereas the improvement in the quality of sleep when taking Trittiko occurs already on the 1st day.

The time of taking the antidepressant is determined by the doctor; on average, it is 6 months. Further use is possible, but is associated with the risk of dependence.

Links of the same chain: pain - decreased activity - depression

Long-term bodily ailment is associated with a change in perception and thinking. Often changes occur imperceptibly for a person, but the inseparable physical and mental manifestations of pain need treatment, like many other diseases.

Pain affects many aspects of a person's daily life: activity, sleep, mood, initiative, well-being and, to the same extent, self-esteem.

A sparing attitude towards one's own body, reduced activity lead to a decrease in physical endurance and a painful reaction to stress. This, in turn, further reduces activity, and ultimately leads to social withdrawal, isolation, and depression.

More than 60% of people suffering from chronic pain complain of sleep disturbances. As a result, they not only notice an increase in pain, but in the future they develop depression and anxiety.

Vicious circle: pain and sleep disturbance

60-80% of people suffering from chronic pain have sleep disorders.

What refers to sleep disorders, from a medical point of view?

1. Trouble falling asleep, waking up in the middle of the night, poor sleep quality.
2. Mentioned violations that occur more than twice a week for a month or more.
3. A significant lengthening of the time of wakefulness by reducing the time of sleep. Fatigue and weakness during the day, disrupting the usual activity.
4. Lack of sleep or poor quality of sleep makes sleep a burden for such people.

The close relationship between sleep and pain sensations has been studied and explained as follows: the pathways along which pain signals are conducted pass near the sleep center in the brain, where they interact.

The signal to wake up occurs in the center of sleep even before the perception of the pain signal, and the person wakes up not from pain, but because of the occurrence of a false signal. If the pain and related sleep disturbances continue, there is a danger of their transition to a chronic form.

Vicious circle: sleep disturbance and pain

There is also an opposite relationship: increased pain due to sleep disturbance.

The sleep structure of a person suffering from chronic pain and a healthy person is significantly different: with pain, the deep sleep phase is shortened, which is important for restoring the body after the pain experienced during the day. The lack of recovery leads to a change in the pain threshold, and the next day the pain is perceived as more intense. The deep sleep phase is also important for skeletal muscle relaxation.

During the night, the deep sleep phase is replaced several times by REM sleep, at which point unwanted awakenings may occur.

The goal of effective therapy for sleep disorders is to restore its normal structure. This is how Trittiko works.

Trittiko:

• Restores the structure of sleep
• Reduces the intensity of pain
• Relieves depression
• anxieties
• Eliminates mental disorders of sexual function

Trittiko has no effect on body weight.

What dosage should I take Tritiiko?

Medicines can work differently for different people. Therefore, it is important to individually select the optimal dose of the drug. Trittiko comes in tablets that are easily divided into 3 parts to make up your dosage. If your doctor has not prescribed a dosage, use the following table:

The usual dosage is 150-300 mg (1-2 tablets) per day.

Start taking with a dose of 50-100 mg and gradually increase it to the prescribed dose.

Older people often need a lower dosage.

How long should I continue taking Trittiko?

The duration of treatment is determined by your doctor, the average duration in the presence of chronic pain and depression is six months.

Mode of application.

How to combine Trittiko with food?

Sometimes taking the drug on an empty stomach can cause nausea. Take Trittiko after meals to avoid discomfort.

Trittiko has a calming, hypnotic effect. Taking the drug in the evening, you will not experience drowsiness during the day. The daily dose can be divided into several doses, but a larger dose should be left for the evening dose.

Be sure to discuss questions regarding the dosage and frequency of taking the drug with your doctor.

Does Trittico have any side effects?

As with any drug, in addition to the main therapeutic effect, there are side effects.

At the very beginning of the reception, such a frequent side effect as depression may appear, and not necessarily associated with taking Trittiko. Sometimes there are drowsiness, fatigue, at the very beginning of treatment - dizziness, nausea. Very rarely, cases of prolonged pathological erection in men (priapism) are described. In such a situation, you should seek medical attention from your doctor or the nearest hospital.

If you experience any side effects, tell your doctor or pharmacist at the pharmacy, carefully read the instructions for use of the drug.

To minimize potential side effects, start Trittico at a low dose. Try to take the drug once a day or leave most of the dose of the drug for the evening.

How do you yourself monitor the progress of pain management?

Never leave your doctor's office without answering all your questions. If you do not understand something, ask your doctor for clarification until everything becomes clear to you. In order not to forget what to ask, you can make a list of questions in advance at home.

Tell your doctor about your problems and worries.

Follow the treatment plan drawn up by your doctor. If you have new complaints, tell your doctor about it - he will adjust the treatment plan.

If the pain does not decrease or increases as well, tell your doctor. Tell him if you sleep well at night. Do not exaggerate or underestimate if you feel unwell. Remember that only you can feel when the pain subsides and sleep becomes complete.

Talk to family and friends about pain management to clear your own preconceptions.

Find out about your illness and treatment options, including psychotherapy (individually and in groups), therapeutic exercises and special exercises.

Try to be physically and socially active, even if it's hard for you.

Be patient – ​​chronic disease management requires a lot of patience.

Be sure to tell those around you if you feel unwell.

Keep in touch, do not remove yourself from communicating with people!

Try to find self-help groups: there are many people who face the same problems as you.

Self-help groups

Summary

• Chronic pain causes serious sleep disturbances
• Sleep disturbances exacerbate pain and lead to impaired social relationships
• Chronic pain, sleep disturbances and depression are closely linked
• The International Standards for Pain Management include prescribing antidepressants regardless of the presence of depression and anxiety
• Trittiko reduces pain and depression, anxiety, sleep disorders and mental disorders of sexual function
• Take Trittiko as directed by your doctor
• Do not start taking Trittiko without the approval of your doctor
• To minimize side effects, start taking the drug with a small dose, gradually increasing it. Take the drug in the evening, after meals.
• For any questions, please contact your physician.

Trittiko is an antidepressant that is widely used in psychiatric practice for the treatment of mental disorders such as depressive states, recurrent depressive episodes, accompanied by anxiety or without it.

The drug effectively affects the somatic (headache, palpitations, frequent urination, muscle pain, hyperventilation, sweating) and mental (irritability, affective tension, insomnia, fear) symptoms of anxiety. It also helps to improve mood, stabilize the emotional state, reduce the pathological craving for alcohol in patients suffering from chronic alcoholism during the withdrawal syndrome and during remission.

Trittico does not affect the neutral uptake of dopamine and norepinephrine, does not affect body weight, and does not lead to addiction.

Clinical and pharmacological group

Antidepressant, a thiazolopyridine derivative.

Terms of sale from pharmacies

Can buy by prescription.

Price

How much does Trittiko cost in pharmacies? The average price is at the level of 690 rubles.

Composition and form of release

Trittiko is available in the form of white tablets, the main active ingredient of which is trazodone hydrochloride. As excipients in Trittiko tablets, carnauba wax, sucrose, povidone, magnesium stearate are used.

Tablets are available in 75 and 150 mg.

pharmachologic effect

Trittiko is a drug synthesized on the basis of trazodone, which is a derivative of triazolpyridine. Effective in the treatment of depressive conditions, as well as pathologies associated with anxiety, problems with falling asleep. Differs in fast action - already within the first week, the antidepressant Trittiko begins to show an effect in eliminating the symptoms of depression.

Trazodone, as an active substance, acts as a serotonin reuptake inhibitor and receptor antagonist, the activation of which is usually associated with the development of anxiety, insomnia, changes in sexual function and psychomotor agitation. Unlike other psychotropic drugs, this antidepressant is approved for use in glaucoma and diseases of the urinary system, does not cause extrapyramidal effects and does not potentiate adrenergic transmission.

It does not have effects on heart function typical of tricyclic antidepressants. It is excreted by half within half a day, mainly with urine in the form of inactive metabolic products. Metabolized in the liver.

Indications for use

This drug is intended for the treatment of the following painful conditions:

• psychogenic depressions (neurotic and reactive depressions);
• benzodiazepine dependence;
• alcoholic depression;
• anxiety-depressive states of an endogenous nature (involutional depressions);
• anxiety-depressive conditions caused by organic diseases of the central nervous system (Alzheimer's disease, dementia, cerebral atherosclerosis, etc.);
• depressive states with prolonged pain syndrome;
• potency and libido disorders (erectile dysfunction disorders in depression).

Contraindications

According to the instructions, Trittiko cannot be used in such cases:

• in the presence of high sensitivity to the components included in the drug;
• lactation period and pregnancy.
• age less than 6 years.

Use with caution in persons with AV blockade, ventricular arrhythmia, myocardial infarction, arterial hypertension, hepatic or renal insufficiency, as well as persons under 18 years of age, due to the risk of developing suicidal behavior (aggression, suicidal plans, anger).

Appointment during pregnancy and lactation

There are no data on harm to the fetus, but if the expectant mother took Trittico before delivery, monitoring of the newborn is required. Take only under medical supervision and with caution.

Trazodone can penetrate into breast milk in small amounts, so it is recommended to interrupt breastfeeding during its use.

Dosage and method of application

As indicated in the instructions for use, Trittiko tablets are taken orally, swallowed whole, washed down with a sufficient amount of water, 0.5 hours before or 2-4 hours after a meal.

• depression with and without anxiety: the initial dose is 100 mg once at bedtime. After three days of therapy, the dose can be increased to 150 mg. Further, until the optimal clinical effect is achieved, the dose should be increased by 50 mg every 3-4 days. If the daily dose exceeds 150 mg, then it should be divided into 2 doses: after dinner, a smaller dose is taken, before bedtime - the main one. The maximum daily dose: for outpatients - 450 mg, for patients in the hospital - 600 mg;
• treatment of impotence: monotherapy - more than 200 mg per day, as part of combination therapy - 50 mg per day;
• treatment of libido disorders: 50 mg per day;
• benzodiazepine dependence: according to the scheme, which provides for a simultaneous decrease in the dose of benzodiazepine by 1/4 or 1/2 tablets and an increase in the dose of trazodone by 50 mg, take for 21 days. Then continue to gradually reduce the dose of benzodiazepines, each time increasing the dose of trazodone. After the complete withdrawal of benzodiazepine, the daily dose of trazodone is reduced by 50 mg with an interval of 21 days.

The initial dose of Trittiko for debilitated and elderly patients should be no more than 100 mg per day. It is selected individually and prescribed once at bedtime or divided into two doses. Increasing the dose should be carried out under the supervision of a physician, taking into account the effectiveness and tolerability of the drug. For this category of patients, it is not recommended to exceed the maximum daily dose of 300 mg.

For children aged 6 to 18 years, the dose is determined taking into account the weight of the child at the rate of 1.5-2 mg per 1 kg of body weight per day and divided into several doses. To achieve the desired therapeutic effect, the initial dose of Trittico can be gradually increased, observing an interval of 3-4 days. The maximum daily dose for children should not exceed 6 mg per 1 kg of body weight.

Side effects

While taking Trittiko tablets, patients may develop some side effects:

• on the part of the digestive system - dry mouth, thirst, pain in the stomach, nausea, intestinal atony, a feeling of heaviness in the abdomen, bloating and flatulence, stool retention, constipation, in severe cases, intestinal obstruction;
• on the part of the skin and the musculoskeletal system - itching, erythematous rash, excessive sweating, pain in the joints, muscle pain;
• from the genitourinary system - priapism, impaired urination;
• on the part of blood parameters - thrombocytopenia, agranulocytosis, eosinophilia, leukopenia, iron deficiency anemia;
• on the part of the nervous system - dizziness and headaches, confusion, phobias, hallucinations, paresthesias, impaired taste sensations, tremor of the limbs, seizures like an epileptic seizure;
• on the part of the cardiovascular system - palpitations, extrasystole of the ventricular type, decrease in blood pressure, fainting, development of acute vascular insufficiency;
• fatigue, drowsiness, apathy, fever, flu-like symptoms.

If one or more side effects occur, treatment with the drug should be discontinued and consult a doctor.

Overdose

In case of an overdose, the following symptoms are noted:

• tachycardia;
• hypotension;
• hyponatremia;
• drowsiness;
• dizziness;
• vomit;
• nausea;
• respiratory failure;
• convulsions.

In cases of severe overdose, a coma develops. Symptomatic complex from the side of the heart may include bradycardia and tachycardia. Symptoms may appear within a day after an overdose and later. Simultaneous use with other antidepressants is dangerous for the development of serotonin syndrome.

The drug has no specific antidote. Adults with an overdose of more than 1 g of trazodone, or children with an overdose of more than 0.15 g, should take activated charcoal within one hour of the onset of overdose symptoms. In other cases, gastric lavage is advisable.

It is necessary to monitor the patient's condition within twelve hours after an overdose. It is recommended to control blood pressure, pulse, blood oxygen saturation. In patients with heart disease, cardiac activity should be monitored.

For short-term convulsions, treatment is not indicated. Frequent and prolonged convulsions are eliminated by intravenous administration of Diazepam or Lorazepam. If these measures did not help to eliminate convulsions, put a dropper of Phenytoin.

With arterial hypotension and sedation, supportive and symptomatic therapy is used.

special instructions

Before you start using the drug, read the special instructions:

1. Drinking alcohol while taking the medication is contraindicated.
2. If, while taking the pills, the patient develops a prolonged and inadequate erection, it is necessary to consult a doctor.
3. The lack of anticholinergic action in Trittiko allows its use in prostatic hypertrophy, angle-closure glaucoma, cognitive impairment, and elderly patients.
4. When prescribing Trittiko to patients with impaired cardiac conduction, AV block or after a recent myocardial infarction, the adrenolytic activity of trazodone and the risk of developing bradycardia and lowering blood pressure should be taken into account.
5. During the period of treatment, it is recommended to periodically conduct a peripheral blood test, including when pain in the throat occurs when swallowing or fever. This will allow timely diagnosis of agranulocytosis and establish cases of severe leukopenia.

During depression, the risk of suicidal thoughts or behavior increases, including against the background of taking antidepressants, especially under the age of 24 years. Therefore, before the onset of a pronounced remission, patients need careful monitoring. If you experience unusual changes in behavior, you should immediately seek advice from your doctor.

Interaction with other drugs

When using the drug, it is necessary to take into account the interaction with other drugs:

1. A case of the development of arrhythmia of the "pirouette" type is described with the simultaneous use of trazodone with amiodarone.
2. A case of a moderately pronounced decrease in the anticoagulant effect of warfarin with simultaneous use with trazodone is described.
3. With simultaneous use with lithium salts, tremor, reversible symptoms of neurotoxic action are possible.
4. When taking pseudoephedrine against the background of trazodone therapy, a case of anxiety, panic, blackout, depersonalization is described.
5. With simultaneous use with ethanol, the inhibitory effect on the central nervous system increases.
6. With simultaneous use, an increase in the concentration of digoxin in the blood plasma and the development of symptoms of intoxication are possible.
7. With simultaneous use with carbamazepine, a case of an increase in the concentration of carbamazepine in the blood plasma is described.
8. With simultaneous use with thioridazine, an increase in the concentration of trazodone in the blood plasma is possible; with tryptophan - a case of development of anorexia, psychosis, hypomania is described; with phenytoin - a case of increased side effects of phenytoin is described; with fluoxetine - possibly increased side effects; with chlorpromazine, trifluoperazine - the development of arterial hypotension is possible.