Ibufen expiration date after opening. Ibufen: instructions for use and reviews

Dosage form

Oral suspension, 100 mg/5 ml 100 ml

Compound

100 ml of suspension contain

active substance - ibuprofen 2.0 g,

Excipients: hypromellose, xanthan gum, glycerin, sodium benzoate, liquid maltitol, sodium citrate dihydrate, citric acid monohydrate, sodium saccharinate, sodium chloride, raspberry flavor, purified water.

Description

A homogeneous suspension of white or almost white color with a raspberry odor.

Pharmacotherapeutic group

Anti-inflammatory and antirheumatic drugs. Non-steroidal anti-inflammatory drugs. Propionic acid derivatives. Ibuprofen

ATX code M01AE01

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Pharmacological properties

Pharmacokinetics

Suction

When taken orally, more than 80% of ibuprofen is absorbed from gastrointestinal tract, reaching maximum concentration in blood plasma after 1 hour.

Eating slows down the absorption of ibuprofen, but does not reduce its bioavailability. When children take ibuprofen in the form of a suspension at a dose of 10 mg/kg, its maximum concentration in the blood is 55 mcg/ml. When taken with food, ibuprofen is absorbed more slowly: (t max) and is 30-60 minutes longer than when taken on an empty stomach and is 1.5-3 hours.

Distribution

Ibuprofen is more than 99% bound to plasma proteins. The main drug-binding proteins are albumin. The volume of distribution of ibuprofen in adults is about 0.12 l/kg body weight, and in children with elevated body temperature under 11 years of age it is higher and is about 0.2 l/kg body weight. The high degree of protein binding limits the rate of penetration of ibuprofen into the synovial and cerebrospinal fluid. Therefore, ibuprofen slowly penetrates into the synovial fluid, maintaining a therapeutic concentration in it for a long time.

Metabolism

Medicine biotransformed mainly in the liver.

Removal

70-90% of the dose taken is excreted in the urine in the form of metabolites and products of their conjugation with glucuronic acid.

The remainder of the dose is excreted in the feces unchanged and also in the form of metabolites. The drug does not accumulate in the body.

Pharmacodynamics

Ibuprofen is a propionic acid derivative that has antipyretic, analgesic and anti-inflammatory effects.

The mechanism of action of ibuprofen is primarily due to the suppression of prostaglandin biosynthesis by reducing the activity of cyclooxygenase (COX), an enzyme that regulates the conversion of arachidonic acid into prostaglandins, prostacyclin and thromboxane. At the same time, as a result of irreversible inhibition of the cyclooxygenase pathway of arachidonic acid metabolism, the formation of prostaglandins decreases. A decrease in the concentration of prostaglandins at the site of inflammation is accompanied by a decrease in the formation of bradykinin, endogenous pyrogens, and other biological active substances, oxygen radicals and nitric oxide. All this leads to a decrease in the activity of the inflammatory process (anti-inflammatory effect of ibuprofen) and is accompanied by a decrease in pain reception (analgesic effect). A decrease in the concentration of prostaglandins in the cerebrospinal fluid leads to normalization of body temperature (antipyretic effect). The temperature lowering effect begins after 30 minutes. after taking it maximum action appears after 3 hours.

Indications for use

Increased body temperature of various origins with:

Colds

Acute respiratory viral infections

Sore throat (pharyngitis)

Children's infections accompanied by increased

body temperature

Post-vaccination reactions

Pain syndrome of various origins of weak and moderate intensity with:

Toothache, painful teething

Headache, migraine

Pain in muscles and joints due to injuries of the musculoskeletal system

Ear pain due to inflammation of the middle ear.

Directions for use and doses

For oral use.

5 ml of suspension contains 100 mg of ibuprofen.

Before use, shake until a homogeneous suspension is obtained.

The drug is taken after meals, with big amount liquids.

For precise dosing of the suspension, a dispenser (spoon or syringe) is attached to the bottle.

The dose is set depending on the age and body weight of the child.

The daily dose of Ibufen® suspension is 20-30 mg/kg body weight. The drug is prescribed in single doses according to the scheme below:

Infants from 3 to 6 months (5-7.6 kg): 3 times 2.5 ml during the day (which corresponds to 150 mg of ibuprofen/day).

Infants from 6 to 12 months (7.7-9 kg): 3 to 4 times 2.5 ml during the day (which corresponds to 150-200 mg of ibuprofen / day).

Children from 1 year to 3 years (10-15 kg): 3 times 5 ml during the day (which corresponds to 300 mg of ibuprofen/day).

Children from 4 to 6 years old (16-20 kg): 3 times 7.5 ml during the day (which corresponds to 450 mg of ibuprofen/day).

Children from 7 to 9 years old (21-29 kg): 3 times 10 ml during the day (which corresponds to 600 mg of ibuprofen/day).

Children from 10 to 12 years old (30-40 kg): 3 times 15 ml during the day (which corresponds to 900 mg of ibuprofen/day).

The drug is intended for symptomatic treatment.

Duration of treatment:

No more than 3 days as an antipyretic

No more than 5 days as a pain reliever.

Doses of the drug are administered at intervals of 6 to 8 hours (or, if necessary, maintain at least a 4-hour interval between doses).
Children under 6 months of age medicinal product should be administered only after medical consultation and prescription of the drug by a doctor.

If symptoms persist or worsen in children 3 to 5 months after taking the drug within 24 hours, consult a doctor. If symptoms persist for more than 3 days while taking the drug in a child aged 6 months to 12 years, you should consult a doctor.

The drug is intended for symptomatic treatment. If symptoms persist or worsen, or new symptoms appear, you should consult a doctor.

Increase in body temperature after vaccination

2.5 ml of suspension is administered once; if necessary, the dose can be repeated after 6 hours. Do not administer more than two doses of 2.5 ml of suspension within 24 hours. If such symptoms occur, you should consult a doctor.

Instructions for use of the syringe dispenser

1. Unscrew the cap of the bottle (press, pressing down, and turn counterclockwise).

2. Press the dispenser firmly into the opening of the bottle neck.

3. Shake the contents of the bottle vigorously.

4. To fill the dispenser, the bottle must be turned upside down, and then carefully move the dispenser piston down, pour in the contents until the desired mark on the scale is reached.

5. Turn the bottle over to its original position and remove the dispenser from it, carefully unscrewing it.

6. Place the tip of the dispenser in the child’s mouth, and then, slowly pressing the piston, introduce the contents of the dispenser.

7. After use, the bottle should be closed by screwing on the cap, and the dispenser should be rinsed with water and dried.

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Side effects and reactions

Infrequently: (³ 1/1000 to< 1/100)

Allergic reactions with skin rash and itching

Abdominal pain, nausea, dyspepsia

Rarely (³ 1/10000 to< 1/1000 )

- vomiting, flatulence, diarrhea, constipation

Headache, dizziness, insomnia, agitation, irritability, feeling tired

Very rarely (< 1/10000 )

Severe hypersensitivity reactions: swelling of the face, tongue and larynx, shortness of breath, tachycardia, hypotension (anaphylaxis, angioedema or severe shock)

Bronchial asthma, exacerbation of bronchial asthma and bronchospasm

Peptic ulcer, perforated ulcer or bleeding from the gastrointestinal tract, melena, vomiting of blood (sometimes fatal, especially in older patients), ulcerative stomatitis, gastritis, exacerbation of ulcerative colitis and Crohn's disease

Visual impairment

Hematopoietic disorders (anemia, leukopenia, thrombocytopenia, pancytopenia, agranulocytosis)

The appearance of edema, arterial hypertension, heart failure due to the use of drugs from the NSAID group

Acute renal failure, papillonecrosis (especially with long-term use), associated with increased serum urea and edema

Liver dysfunction, especially during long-term use

Severe forms of skin reactions may develop, such as bullous reactions, including erythema multiforme, toxic epidermal necrolysis, Stevens-Johnson syndrome

Symptoms of aseptic meningitis: stiff neck, headache, nausea, vomiting, fever or disorientation, especially in patients with pre-existing autoimmune disorders (systemic lupus erythematosus, mixed connective tissue disease)

Psychotic reactions, depression

If side effects occur, you should stop using the drug.

Contraindications

Hypersensitivity to ibuprofen or other components of the drug, as well as to other non-steroidal anti-inflammatory drugs

medicines

Bronchial asthma, urticaria, rhinitis, provoked by taking acetylsalicylic acid (salicylates) or other NSAIDs

Concomitant use of other NSAIDs, including specific cyclooxygenase-2 inhibitors

Ulcerative lesions of the gastrointestinal tract (peptic ulcer of the stomach and duodenum, ulcerative colitis)

Gastrointestinal bleeding

History of gastrointestinal bleeding or perforation associated with NSAID therapy

Hemorrhagic vasculitis

Blood diseases (bleeding tendency, hemophilia, hypocoagulation)

Severe renal or liver failure

Severe heart failure

III trimester of pregnancy

Children's age up to 3 months

Drug interactions

Ibufen® (as well as other drugs from the NSAID group) should not be used simultaneously with the following drugs:

- acetylsalicylic acid, other NSAIDs and corticosteroids: the risk of developing side effects from the gastrointestinal tract increases

Caution must be exercised when used simultaneously with the following drugs:

- antihypertensive drugs and diuretics: since simultaneous use with NSAIDs reduces their effectiveness

- antithrombotic drugs: NSAIDs may increase the effect of drugs that reduce blood clotting

- lithium, methotrexate, digoxin and phenytoin: NSAIDs may increase plasma concentrations of these drugs (periodic serum monitoring is recommended)

- zidovudine: Possible increase in bleeding time when used simultaneously with ibuprofen

- antiplatelet drugs and selective serotonin reuptake inhibitors (SSRIs): there is an increased risk of developing gastrointestinal bleeding

- mifepristone: NSAIDs should not be used for 8-12 days after taking mifepristone as NSAIDs may reduce its effect

- tacrolimus, cyclosporine: the risk of nephrotoxicity increases with simultaneous use of ibuprofen with these drugs

- quinolone antibiotics: Patients taking a combination of NSAIDs and quinolones may be at risk of seizures

- potassium-sparing diuretics: simultaneous use with ibuprofen can lead to the development of hyperkalemia

- probenecid, sulfinpyrazone: These drugs may inhibit the elimination of ibuprofen

special instructions

Caution should be exercised in persons with renal failure, circulatory insufficiency or liver dysfunction.

For persons with bronchial asthma or symptoms of allergic reactions to acetylsalicylic acid, as well as those taking other medications (especially antihypertensive, diuretic, cardiotropic and psychotropic drugs), the use of the drug is permissible only if great caution is observed.

Isolated cases of toxic amblyopia have been reported with the use of ibuprofen.

Considering the possibility of disorders of the digestive system, it is necessary to avoid simultaneous use of ibuprofen with substances or medications that have an ulcerogenic effect (including acetylsalicylic acid, corticosteroids).

Gastrointestinal bleeding, ulcer formation and perforation.

Gastrointestinal bleeding, ulceration or perforation, which in some cases resulted in death, was observed after use of all NSAIDs in each treatment period, with or without previous symptoms or episodes of gastrointestinal bleeding (including ulcerative colitis, Crohn's disease).
The risk of gastrointestinal bleeding, ulceration, or perforation increases with increasing doses of NSAIDs in patients with a history of peptic ulcer disease, especially complicated by bleeding or perforation, and in the elderly.

If gastrointestinal bleeding or ulceration occurs, you should immediately stop taking the drug.

Patients with a history of gastrointestinal diseases, especially the elderly, should be warned to report any unusual gastrointestinal symptoms (especially bleeding) to the physician, especially at the beginning of treatment. These patients should take the minimum effective dose of the drug.

Caution should be exercised when using the drug in patients concomitantly taking other drugs that may increase the risk of gastrointestinal disturbances or bleeding, such as corticosteroids, anticoagulants such as warfarin, selective serotonin reuptake inhibitors, or antiplatelet agents (such as acetylsalicylic acid ).

Disorders of the cardiovascular system and cerebral circulation

Patients with a history of hypertension and/or mild to moderate heart failure require monitoring and counseling as fluid retention, increased blood pressure, and edema may occur with NSAID therapy.

According to the results of clinical studies and epidemiological data, the use of ibuprofen, especially in high doses (2400 mg daily) and for a long time, may be accompanied by an increased risk of arterial thrombosis (for example, myocardial infarction or stroke). In general, epidemiological studies show that low doses of ibuprofen (eg, less than 1200 mg/day) do not increase the risk of myocardial infarction.

Skin reactions

Very rare cases of severe skin reactions (sometimes fatal), such as exfoliative dermatitis, Stevens-Johnson syndrome and toxic epidermal necrolysis (Lyell's syndrome), have been described in association with the use of NSAIDs. Apparently, patients are at greatest risk of developing skin reactions during the initial period of therapy, since in most cases these reactions develop during the first month of treatment. At the first sign of a skin rash, lesions of the oral mucosa, or other symptoms of hypersensitivity, the drug should be discontinued.

In exceptional cases, chickenpox can cause serious infectious complications of the skin and soft tissues. At present, a role for NSAIDs in the treatment of such infections cannot be ruled out. Therefore, it is recommended to avoid the use of ibuprofen for smallpox.

At the same time, long-term use of various analgesic drugs can lead to kidney damage with the risk of developing renal failure (analgesic nephropathy).

Isolated cases of toxic amblyopia have been reported when using ibuprofen, so you should inform your doctor about any visual disturbances.

Children and teenagers who are dehydrated are at risk of kidney failure.

This medicine contains liquid maltitol. This drug should not be used in patients with hereditary fructose intolerance (a rare genetic disorder).

Pregnancy and lactation periodAnd

There is no comprehensive information regarding the safety of ibuprofen in women during pregnancy. Since the effect of inhibition of prostaglandin synthesis on the human fetus remains unknown, the use of ibuprofen in the first and second trimester of pregnancy is not recommended.

The use of ibuprofen in the third trimester of pregnancy is contraindicated, since it promotes premature closure of the ductus arteriosus and can cause pulmonary hypertension in the newborn; the drug also suppresses the contractile activity of the uterus, which delays the onset of labor and prolongs labor, and also increases the risk of bleeding in the mother and child

Lactation

Ibuprofen and its metabolites pass into breast milk in very low concentrations. Since there have so far been no reports of negative effects on newborns, with short-term use of the drug there is no need to stop breastfeeding.

Fertility

There are reports that the use of drugs that inhibit cyclooxygenase/prostaglandin synthesis may affect ovulation and thereby negatively affect the reproductive capacity of women. These effects stop when you stop taking the drug.

NSAIDs may mask symptoms of infection and fever.

Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms

When taking Ibufen®, dizziness may occur, which should be taken into account when driving a vehicle and servicing moving machinery.

Overdose

Symptoms: Nervous system disorders such as headache, dizziness, lightheadedness and loss of consciousness (with myoclonic convulsions in children), abdominal pain, nausea and vomiting. Gastrointestinal bleeding, functional disorders of the liver and kidneys, decreased blood pressure, respiratory depression and cyanosis are possible.

Store at a temperature not exceeding 25°C. Store in original packaging. Keep the bottle tightly closed.

Keep out of the reach of children!

Shelf life

After opening the package for the first time, the bottle must be used

within 6 months.

Do not use after the expiration date stated on the package.

Painkillers and antipyretics are the most popular types of drugs on the pharmacological market. Millions of people need these funds every day. Some people need drugs to relieve headaches or toothaches, others use them to eliminate the symptoms of viral diseases. Some people have to take these medications throughout their lives. Modern drug manufacturers produce a wide variety of tablets, capsules, and suspensions. Ibuprofen-based medications are very popular. This component is included in the drug "Ibufen Ultra". Instructions and features of its use will be described for you today.

Preface

Pain is a natural reaction of the human body to irritant nerve endings. It can be caused by various reasons. able to block this unpleasant feeling. It is important to take the medications correctly. Most home medicine cabinets contain different types of pain relievers. Some have a relaxing effect on smooth muscles and relieve spasms. Others inhibit the synthesis of certain enzymes.

Most painkillers are sold without a prescription. This allows the patient to use the medicine independently if bothersome symptoms occur. It is believed that the drug "Ibufen Ultra" is not only effective, but also safe. Is it really? It is worth learning about this remedy in more detail before using it.

Composition and description

The instructions position Ibufen Ultra tablets as an anti-inflammatory, analgesic that also helps reduce elevated body temperature. Each capsule contains 200 mg of the active ingredient, which is ibuprofen. The drug is produced with the addition of minor substances: macrogol, potassium hydroxide and water. Each pill is coated with a gelatin coating, which allows the original composition to be delivered to the stomach.

The medicine is sold in 10 or 20 blue capsules per package (1 or 2 blisters, respectively). The trade name is indicated in large letters on the pack: “Ibufen Ultra”. Instructions are included with each unit of the drug. At the pharmacy you can also buy Ibufen Ultra suspension, which is most often used for children.

Efficacy of the drug

How does Ibufen Ultra work? The instructions say that the active substance is detected in maximum quantities within an hour after taking the tablet. If you take the drug during meals, this interval may double. Ibuprofen penetrates tissues and joints and helps reduce vascular permeability. The medicine blocks the synthesis of prostaglandins, which promotes anti-inflammatory effects. The antipyretic effect occurs on average 30-45 minutes after taking the tablet, and the analgesic effect occurs after 10-20 minutes. The effectiveness of the drug lasts for 8-12 hours, but in some cases it may be less or more.

Who is prescribed Ibufen Ultra?

The instructions for use recommend the drug for emergency use for pain and fever. The manufacturer allows you to take the pills on your own, but still recommends consulting a doctor first. If you read the annotation, you will find out that the medicine helps cope with the following problems:

• febrile syndrome caused by various reasons (viral or bacterial disease, colds, vaccination, poisoning, intoxication);
• pain (dental, headache, joint, caused by injury);
• periodic ailments in women;
• inflammatory processes in the body.

Restrictions on use

Despite the fact that the instructions for use position Ibufen Ultra as a safe drug, the medicine has its contraindications. The medication should not be used under the following circumstances:

• high sensitivity to ibuprofen;
• intolerance to non-steroidal anti-inflammatory drugs;
• acetylsalicylic acid;
• acute intestinal or stomach ulcer;
• renal or liver failure;
• blood diseases;
• pregnancy in the 1st and 3rd trimesters;
• children under 6 years of age.

"Ibufen Ultra": instructions

For children and adults, the medication is prescribed for internal use. The capsule should be taken with clean water. The tablet is not opened or chewed beforehand. To speed up the effect of the medicine, it is advisable to take it at the beginning of a meal or 1-2 hours after it. If you take the drug during a meal, it may act more slowly.

Adult patients and children over 12 years of age must take Ibufen Ultra 200 mg. The instructions allow the use of a double dose (400 mg). The daily volume of medication should not exceed 1200 mg, which is equivalent to six tablets. Repeated use of the drug is carried out no earlier than 4 hours after the first use.

The duration of use of painkiller capsules should not exceed five days. If the medicine is taken to reduce body temperature, then therapy can be carried out for only three days. Lack of improvement after the specified time obliges the consumer to consult a doctor.

Adverse reactions and consequences of drug overdose

What happens if you use large doses of Ibufen Ultra (tablets)? The instructions for use warn the consumer against this, indicating the daily and one-time dosage. An overdose of the drug causes a decrease in blood pressure, lethargy, and drowsiness. The patient may lose consciousness and fall into a coma. Poisoning with high doses of the drug is accompanied by nausea, vomiting, diarrhea and other symptoms of intoxication. In case of overdose, be sure to consult a doctor to take action. It is permissible to induce vomiting on your own (if the drug has been taken recently) and use the sorbent.

Ibufen Ultra tablets - the instructions say - are usually well tolerated. In rare cases, they may cause an unpleasant reaction, called a side effect. You should consult a doctor if the following symptoms appear after taking the drug:

• nausea, heartburn, abdominal pain, stool upset and other intestinal manifestations;
• headache, drowsiness or agitation;
• changes in blood pressure;
• allergies (swelling, rash, itching, urticaria).

The drug can affect the condition of the blood. It is quite difficult to notice these changes on your own. Therefore, in case of any kind of deterioration in health, you should consult a doctor.

Possibility of use with other drugs

The instructions for use of the drug "Ibufen Ultra 200" allow it to be used simultaneously with other medications. However, taking some drugs along with a pain reliever may affect the patient's well-being in a way that is not expected. The instructions describe the features of complex therapy. Before using other medications, be sure to read this paragraph.

• The simultaneous use of acetylsalicylic acid and other types of NSAIDs increases the likelihood of a negative reaction from the digestive system.
• Diuretic and laxative compounds reduce the effectiveness of antipyretic drugs and reduce their anti-inflammatory effect.
• Caution should be used when using Ibufen Ultra capsules together with anticoagulants. When combined, these drugs increase the likelihood of bleeding.
• It should not be used together with drugs containing lithium, as its content in the body increases.
• Steroid drugs taken together with Ibufen Ultra increase the likelihood of side effects of the latter.
• Antacids reduce the absorption efficiency of the active substance in Ibufen Ultra capsules.

Taking the drug along with caffeine-containing drinks enhances the analgesic effect. In combination with alcohol, the toxic effect on the liver increases.

additional information

There are certain groups of patients who need to consult a doctor before using the drug. This includes:

• nursing women;
• people with any liver and kidney diseases;
• children under 12 years of age;
• allergy sufferers;
• patients with bronchial asthma;
• ulcers;
• hypertensive patients.

If you need to take Ibufen Ultra for a long time, you need to periodically monitor your blood counts.

Doctors about the drug

Doctors strongly recommend that before using the drug “Ibufen Ultra” (capsules), the instructions should be studied by each consumer. Doctors say that this medication is proven and safe. It is used most often. It has even less negative effect on the liver than the famous Paracetamol. Experts warn that the medication increases the risk of bleeding. Therefore, you should not use this remedy before surgical interventions. Even if you are having a routine tooth extraction, give preference to other analgesics. Doctors do not recommend taking the medicine when it comes to abdominal pain. Of course, the drug will help alleviate the condition. But this will make it difficult to make a correct diagnosis. A blurred clinical picture will not allow doctors to provide the necessary assistance to the patient in a timely manner.

What are consumers saying?

Most of the patients who have once used Ibufen Ultra leave positive reviews about it. The medication, people say, effectively helps cope with painful sensations. Women use painkillers during menstruation. It allows you not to change your usual lifestyle and work. You can hear reviews about the drug that report its weak effect. Patients say that they took the medicine to reduce their temperature. At the same time, the capsules helped, but not completely. That is, the thermometer values ​​decreased by 1-1.5 degrees, but did not return to normal.

The manufacturer does not recommend deviating from the standards of use prescribed in the instructions. But some patients manage to take the medicine according to their own rules. There are cases where parents gave capsules to children under 12 years of age. However, they did not notice any negative reactions. The drug did its job perfectly. New mothers said that they had to take Ibufen Ultra during pregnancy. They did not experience any bleeding or other consequences.

Alternative remedies

It is not uncommon for a patient to need to change a drug. You can choose structural analogues and drugs that are similar in action. Absolute substitutes include all medications that contain the active ingredient ibuprofen. The most popular drug today is Nurofen. It is available in different forms: tablets, capsules, suppositories, suspension. This medicine is prescribed to children from three months of age. Other alternative remedies are less popular, but no less effective: Advil, Mig, Brufen, and so on.

If a patient is allergic to ibuprofen, it is advisable to replace it with another medicine that has a similar effect. Analgesic and antipyretic effects can be obtained by using the following drugs: Paracetamol, Panadol, Analgin, Next, Baralgin, Pentalgin, Nise, Nimulid, Ketonol and many others. Every pharmacist can choose a replacement for Ibufen Ultra. But it is better to consult a doctor before using any other medication.

Let's summarize

Today you learned what the instructions for use tell the consumer about the drug “Ibufen Ultra”. The capsules are also presented for your review (photo). Every person sooner or later needs to use antipyretics. The reviews that are generated subsequently can be good or bad. Don't blindly rely on them. The same medicine has different effectiveness for different diseases. In order for the drug to really help and its use to be safe, you need to consult a doctor and get individual prescriptions. Good health, live without pain!

Children often suffer from infectious diseases; young parents need to know which medications are suitable for young patients. Ibufen for children will help reduce body temperature and eliminate pain. A special formula is developed for the child’s body, it quickly copes with the task, the suspension (syrup) is easy to use, children like the pleasant taste and aroma.

How and in what quantities to give Ibufen for children, what are the indications and contraindications for the drug? Answers to questions of interest to young parents are described in the following material.

Pharmacological properties

Ibufen belongs to the group of non-steroidal anti-inflammatory drugs. The drug has an antipyretic and analgesic effect. The positive effect of the medication is ensured by the main active ingredient – ​​ibuprofen. The component inhibits the enzyme cyclooxygenase, which affects the metabolism of arachidonic acid, which helps reduce prostaglandins.

The process leads to a decrease in the inflammatory process, since the latter substance is responsible for the pathological condition in the child’s body. Body temperature returns to normal, the active component of the syrup for children prevents excitation of the temperature center of the brain and reduces the concentration of pain impulses.

An analgesic and antipyretic agent is achieved much faster than the anti-inflammatory effect. To relieve unpleasant symptoms, a smaller dose of medication is required than to eliminate the source of inflammation. The anti-inflammatory effect is observed only on the seventh day of treatment with Ibufen for children.

Most of the active components of the drug are absorbed by the gastrointestinal tract. The lion's share of the drug is excreted in the bile. The maximum antipyretic effect is achieved half an hour after taking the drug and lasts for eight hours; the specific duration of action depends on the individual characteristics of the baby’s body and metabolic rate.

Composition and release form

Ibufen for children is available in the form of a suspension, some call the medicine syrup. The product has a pleasant orange taste and aroma, and orange color. Additionally, they produce syrup with raspberry and strawberry flavors. The formation of sediment is allowed, but after shaking, the suspension becomes homogeneous in consistency. The drug is packaged in dark glass bottles; there is also a measuring spoon or a special syringe that allows you to measure the required amount of medication. Each vessel is packed in a cardboard box and is sold without a prescription.

The main active ingredient is ibuprofen, it performs the main function of coping with fever in a child and relieving pain. Auxiliary components include:

• sucrose,
• glycerol,
• citric acid monohydrate,
• orange flavor,
• yellow dye,
• purified water.

Additional components perform an auxiliary function and provide the suspension with a pleasant taste and aroma.

Indications for use

The drug has a wide range of pharmacological effects and is used in many cases. The medicine is used as an antipyretic:

• for influenza and acute respiratory infections;
• during the course of colds;
• for childhood infectious diseases accompanied by fever;
• to eliminate high fever after vaccination of the baby.

Ibufen is actively used to relieve pain in various conditions:

• headache;
• strong;
• when, the process in most cases is accompanied by unpleasant sensations;
• for various injuries, burns;
• muscle pain of various etiologies.

Contraindications

It is forbidden to use Ibufen for children:

• in case of hypersensitivity to individual components of the drug, hypersensitivity to ibuprofen or other components of the drug;
• after the appearance of negative reactions (urticaria, skin rashes, itching, angioedema) to another non-steroidal medication of a similar drug, which included acetylsalicylic acid;
• for diseases of the kidneys and liver, especially during exacerbations of ailments;
• during the course of blood diseases;
• for children up to three months of age;
• for peptic ulcers of the stomach or duodenum, gastritis, and other serious ailments of the gastrointestinal tract.

An effective drug copes with many symptoms of various diseases, quickly copes with the task, and is produced specifically for young and middle-aged children. It is not justified to consider a medicine absolutely safe; the medicine is produced for children, but has contraindications, and violation of these rules is fraught with the appearance of sharply negative reactions.

Possible side effects and overdose

If the dosage is not observed, or individual intolerance to the main and auxiliary components, the following negative consequences may occur:

• headache, dizziness, anxiety, causeless whims, sleep disturbances, blurred vision. In difficult cases – depression, severe intoxication of the body;
• decreased appetite, constant, exacerbation of chronic diseases of the gastrointestinal system;
• Sometimes a small patient experiences tachycardia and increased blood pressure;
• acute renal failure, cystitis;
• allergic, Quincke's edema, other allergy symptoms.

If you notice any side effects, be sure to stop taking the medication. Show the baby to the doctor, sometimes symptomatic treatment is required, in severe cases - hospitalization of the little patient.

The product contains sugar and is not recommended for children with. With prolonged use, the medication can disrupt the acid balance in the stomach and intestines, which leads to bleeding. Regular examination of the body and carrying out certain manipulations will help to avoid negative consequences.

Instructions for use and dosage

Children's Ibufen is recommended to be taken with an eight-hour break, periodically. If you violate this interval, the likelihood of an overdose increases many times. According to the instructions, the drug is allowed to be used in childhood and adolescence. The daily dose is calculated based on the child’s body weight, a single dose is from five to ten milligrams per kilogram of the baby’s weight. In emergency situations, the dosage is increased to 20-30 milligrams per kilogram of baby weight.

The drug is taken orally, first warm the drug to room temperature, shake, and start using the medication:

• open the cap by first turning and pressing on it;
• press the special dispenser into the opening of the bottle;
• Shake the contents again until a homogeneous suspension is formed;
• to take the drug, turn the bottle upside down, pull the dispenser lever down to the required mark;
• return the bottle to its original position, unscrew the dispenser in a circular motion with smooth movements;
• Insert the tip of the piston into the baby’s oral cavity, slowly put it on the piston until all the medication enters the baby’s body;
• After using the medicine, screw on the cap of the bottle, rinse the dispenser under running water, and dry.

An approximate scheme for using Ibufen for children is indicated in the instructions for the medicinal product:

• babies from six to twelve months - no more than 2.5 ml three times a day;
• from one to three years – five milliliters three times a day;
• for children from four to six years old - give 7.5 ml three times a day;
• children from seven to nine years old are allowed to give 10 milliliters three times a day;
• for children from ten to twelve years old - the maximum permissible dose is 15 ml up to three times a day.

The drug must not be combined with medications that include acetylsalicylic acid. It is also not recommended to use Ibufen in combination with other anti-inflammatory and antipyretic drugs. The combination of these drugs negatively affects the course of the disease and increases the risk of negative reactions many times over.

Find out about the rules of use and dosage for cough in children.

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Read here about how and how to treat allergies in a newborn while breastfeeding.

Storage conditions and cost

It is recommended to store the pharmaceutical product in a dark place; be sure to limit access to children. Young patients often taste medications; if they like the medication, there is a high risk of overdose. The temperature should not exceed 25 degrees Celsius. The maximum shelf life of the medicinal product is 3 years; after opening the bottle, use the medicine for six months. After the expiration date, the use of the drug is strictly prohibited.

The price of Ibufen syrup for children is approximately 300 rubles per 100 ml bottle; a similar 200 ml package in pharmacies costs approximately 450 rubles. The specific amount varies depending on the city of purchase, the pharmacy chain, even the time of year (pharmaceutical companies raise the cost of anti-inflammatory drugs during outbreaks of infectious diseases).

Effective analogues

The pharmaceutical industry offers many similar remedies to relieve fever and pain. Medicines differ in pricing policy, but in most cases the main component remains unchanged, and the auxiliary components also change. It is prohibited to choose a medication for your child on your own; before replacing Ibufen, be sure to consult a specialist.

Analogs of a medicinal product include:

• Advil for children;
• Deblock;
• Ibuprom;
• Yprene;
• Nurofen for children;
• Sedalgin Sprint;
• Ibuprofen and others.

All medications must be taken according to the instructions, taking into account the age of the child.

in orange glass bottles of 100 g; There is 1 bottle in the box (a measure with a scale is included in the package).

Description of the dosage form

An orange-colored suspension with an orange smell and a sweet taste, with an easily noticeable burning aftertaste. There may be separation into a liquid layer and a sediment, which after mixing form a homogeneous suspension.

pharmachologic effect

Antipyretic, analgesic, anti-inflammatory. Blocks arachidonic acid cyclooxygenase and reduces PG synthesis. The antipyretic effect is due to a decrease in the concentration of PG in the cerebrospinal fluid, a decrease in excitation of the thermoregulation center, which results in the normalization of body temperature. The analgesic effect is associated with a decrease in the production of PG classes E, F, I, biogenic amines, a change in the sensitivity of nociceptors and the prevention of the development of hyperalgesia. The analgesic effect is most pronounced for inflammatory pain. The anti-inflammatory effect is due to a decrease in the secretion of inflammatory mediators and a decrease in the activity of the exudative and proliferative phase of the inflammatory process. The antipyretic and analgesic effect appears earlier and at lower doses than the anti-inflammatory effect, which occurs on the 5-7th day of treatment.

Pharmacokinetics

After oral administration, more than 80% is absorbed from the gastrointestinal tract. Cmax in blood plasma is achieved when taken on an empty stomach - after 45 minutes, when taken after meals after 1.5-2.5 hours. Protein binding - 90%. Slowly penetrates into the joint cavity, but in the synovial fluid it creates higher concentrations than in the blood plasma (Cmax in the synovial fluid is reached after 2-3 hours). Metabolized mainly in the liver. Subject to pre- and post-systemic metabolism. After absorption, about 60% of the pharmacologically inactive R-form is slowly transformed into the active S-form. Excreted by the kidneys (60-90% in the form of metabolites and products of their combination with glucuronic acid, to a lesser extent - with bile, unchanged - no more than 1%). It has a two-phase elimination kinetics with T1/2 2-2.5 hours, after taking a single dose it is completely eliminated within 24 hours. The antipyretic effect of Ibufen develops after 30 minutes and lasts 6-8 hours.

Indications for Ibufen

As an antipyretic: for colds, acute respiratory viral infections, flu, sore throat (pharyngitis), childhood infections accompanied by fever, post-vaccination reactions.

As a pain reliever: for toothache, painful teething, headaches, migraines, neuralgia, pain in muscles, joints, injuries and burns.

Contraindications

Hypersensitivity (including to acetylsalicylic acid or other NSAIDs), peptic ulcer of the stomach and duodenum, severe failure of the liver, kidneys, cardiovascular system, arterial hypertension, hemophilia, hypocoagulation, hemorrhagic diathesis, deficiency of glucose-6-phosphate dehydrogenase , bronchospastic reactions after the use of acetylsalicylic acid or other NSAIDs (“aspirin asthma”), Quincke’s edema, nasal polyps, hearing loss, infancy (up to 6 months, with body weight below 7 kg).

Side effects

From the central nervous system: headache, dizziness, sleep disturbance, anxiety, drowsiness, depression, agitation, visual impairment (reversible toxic amblyopia, blurred vision or double vision).

From the hematopoietic organs: heart failure, tachycardia, increased blood pressure; anemia, thrombocytopenia, agranulocytosis, leukopenia.

From the gastrointestinal tract: nausea, vomiting, loss of appetite, heartburn, abdominal pain, diarrhea, constipation, flatulence, liver dysfunction, peptic ulcers, gastric bleeding.

From the urinary system: acute renal failure, allergic nephritis, nephrotic syndrome (edema), polyuria, cystitis.

Allergic reactions: itching, rash, bronchospastic syndrome, allergic rhinitis, Quincke's edema, Steven-Johnson syndrome, Lyell's syndrome.

Interaction

It should not be combined with other NSAIDs (acetylsalicylic acid reduces the anti-inflammatory effect and increases side effects). When taken simultaneously with diuretics, the diuretic effect is reduced and the risk of developing renal failure increases. Weakens the effect of antihypertensive drugs, incl. ACE inhibitors (at the same time reduces their excretion by the kidneys), beta-adrenergic agents, thiazides. Enhances the effect of oral hypoglycemic agents (especially sulfonylurea derivatives) and insulin, indirect anticoagulants, antiplatelet agents, fibrinolytics (increases the risk of hemorrhagic complications), the toxic effect of methotrexate and lithium preparations, increases the concentration of digoxin in the blood.

Inducers of microsomal oxidation (phenytoin, ethanol, barbiturates, zixorin, rifampicin, phenylbutazone, tricyclic antidepressants) increase the risk of severe hepatotoxic complications (increase the production of hydroxylated active metabolites), inhibitors of microsomal oxidation reduce it. Caffeine enhances the pain-relieving effect.

Directions for use and doses

Inside, after meal. The average single dose is 5-10 mg/kg body weight 3-4 times a day. Children aged 6 months - 1 year (7-9 kg)- 2.5 ml (50 mg) 3 times a day, maximum daily dose - 7.5 ml (150 mg). 1-3 years (10-15 kg)- 2.5 ml (50 mg) 3-4 times a day, maximum daily dose - 7.5-10 ml (150-200 mg). 3-6 years (16-20 kg)- 5 ml (100 mg) 3 times a day, maximum daily dose - 15 ml (300 mg). 6-9 years (21-30 kg)- 5 ml (100 mg) 4 times a day, maximum daily dose - 20 ml (400 mg). 9-12 years (31-41 kg)- 10 ml (200 mg) 3 times a day, maximum daily dose - 30 ml (600 mg). Over 12 years old (over 41 kg)- 10 ml (200 mg) 4 times a day, maximum daily dose 40 ml (800 mg). The dose can be repeated every 6-8 hours. Do not exceed the maximum daily dose. For children from 6 months to 1 year, the drug is prescribed on the recommendation of a doctor.

Overdose

Symptoms: abdominal pain, nausea, vomiting, lethargy, headache, tinnitus, depression, drowsiness, metabolic acidosis, hemorrhagic diathesis, decreased blood pressure, acute renal failure, liver dysfunction, tachycardia, bradycardia, atrial fibrillation; convulsions, apnea and coma (especially typical for children under 5 years of age).

Treatment: gastric lavage, administration of activated carbon, alkaline drinking, symptomatic therapy (correction of acid-base balance, blood pressure).

Precautionary measures

Use with caution in case of liver cirrhosis with portal hypertension, liver and/or renal failure, heart failure, nephrotic syndrome, hyperbilirubinemia, gastric and duodenal ulcers (history), gastritis, enteritis, colitis, blood diseases (leukopenia, anemia). , pregnancy (II-III trimesters), during breastfeeding. In patients with bronchial asthma or other diseases associated with bronchospasm, the risk of developing bronchospasm may be increased.

During long-term treatment, monitoring of the peripheral blood picture and the functional state of the liver and kidneys is necessary. When symptoms of gastropathy appear, careful monitoring is indicated (esophagogastroduodenoscopy, blood test with determination of hemoglobin, hematocrit, stool test for occult blood).

If there is no antipyretic effect within 2 days and no analgesic effect within 3 days, you should consult a doctor. If side effects occur, you should stop taking the drug and consult a doctor.

special instructions

Before use, the bottle must be shaken until a homogeneous suspension is obtained. With long-term use, NSAIDs can cause damage to the gastric mucosa, peptic ulcers, and gastrointestinal bleeding.

Patients with diabetes should take with caution - it contains sugar.

If side effects occur, you should stop taking the drug and consult a doctor.

Storage conditions for the drug Ibufen

In a place protected from light, at a temperature not exceeding 25 °C, in the original packaging.

Keep out of the reach of children.

Shelf life of Ibufen

3 years.

Do not use after the expiration date stated on the package.

Synonyms of nosological groups

Category ICD-10	Synonyms of diseases according to ICD-10
G43 Migraine	Migraine pain
	Hemicrania
	Hemiplegic migraine
	Migraine headache
	Migraine
	Migraine attack
	Serial headache
J02.9 Acute pharyngitis, unspecified	Purulent pharyngitis
	Lymphonodular pharyngitis
	Acute nasopharyngitis
J06 Acute upper respiratory tract infections of multiple and unspecified localization	Bacterial infections of the upper respiratory tract
	Bacterial respiratory infections
	Pain due to colds
	Pain in infectious and inflammatory diseases of the upper respiratory tract
	Viral respiratory disease
	Viral respiratory tract infections
	Inflammatory disease of the upper respiratory tract
	Inflammatory diseases of the upper respiratory tract
	Inflammatory diseases of the upper respiratory tract with difficult to separate sputum
	Inflammatory diseases of the respiratory tract
	Secondary infections with influenza
	Secondary infections due to colds
	Influenza conditions
	Difficulty secreting sputum in acute and chronic respiratory diseases
	Upper respiratory tract infections
	Upper respiratory tract infections
	Respiratory tract infections
	Respiratory and lung infections
	ENT infections
	Infectious and inflammatory diseases of the upper respiratory tract
	Infectious and inflammatory diseases of the upper respiratory tract and ENT organs
	Infectious and inflammatory diseases of the upper respiratory tract in adults and children
	Infectious and inflammatory diseases of the upper respiratory tract
	Infectious inflammation of the respiratory tract
	Respiratory tract infection
	Qatar of the upper respiratory tract
	Catarrhal inflammation of the upper respiratory tract
	Catarrhal disease of the upper respiratory tract
	Catarrhal phenomena from the upper respiratory tract
	Cough in diseases of the upper respiratory tract
	Cough with a cold
	Fever due to influenza
	ARVI
	acute respiratory infections
	Acute respiratory infection with symptoms of rhinitis
	Acute respiratory infection
	Acute infectious-inflammatory disease of the upper respiratory tract
	Acute cold
	Acute respiratory disease
	Acute respiratory disease of influenza nature
	Sore throat or nose
	Cold
	Colds
	Colds
	Respiratory infection
	Respiratory viral infections
	Respiratory diseases
	Respiratory infections
	Recurrent respiratory tract infections
	Seasonal colds
	Seasonal colds
	Frequent colds and viral diseases
J11 Influenza, virus not identified	Flu pain
	Flu
	Flu in the initial stages of the disease
	Flu in children
	Influenza condition
	Influenza
	Beginning flu state
	Acute parainfluenza disease
	Parainfluenza
	Parainfluenza condition
	Influenza epidemics
K00.7 Teething syndrome	Pain syndrome during teething
	Painful teething
	Painful tooth growth
K08.8.0* Toothache	Anesthesia in dentistry
	Pain syndromes in dental practice
	Dentin pain
	Pulp pain
	Pain after tartar removal
	Pain after dental procedures
	Pain during tooth extraction
	Dentin pain
	Toothache
M25.5 Joint pain	Arthralgia
	Pain syndrome in osteoarthritis
	Pain syndrome in osteoarthritis
	Pain syndrome in acute inflammatory diseases of the musculoskeletal system
	Pain in the joints
	Joint pain
	Joint pain during heavy physical activity
	Painful inflammatory joint lesions
	Painful joint conditions
	Painful traumatic joint lesions
	Shoulder pain
	Joint pain
	Joint pain
	Joint pain due to injury
	Musculoskeletal pain
	Osteoarthritis pain
	Pain due to joint pathology
	Rheumatoid arthritis pain
	Pain in chronic degenerative bone diseases
	Pain in chronic degenerative joint diseases
	Osteoarticular pain
	Rheumatic pain
	Rheumatic pains
	Joint pain
	Joint pain of rheumatic origin
	Joint pain syndrome
	Joint pain
M79.1 Myalgia	Pain syndrome in muscular and joint diseases
	Pain syndrome in chronic inflammatory diseases of the musculoskeletal system
	Pain in the muscles
	Muscle soreness
	Muscle soreness during heavy physical activity
	Painful conditions of the musculoskeletal system
	Pain in the musculoskeletal system
	Muscle pain
	Pain at rest
	Muscle pain
	Muscle pain
	Musculoskeletal pain
	Myalgia
	Myofascial pain syndromes
	Muscle pain
	Muscle pain at rest
	Muscle pain
	Muscle pain of non-rheumatic origin
	Muscle pain of rheumatic origin
	Acute muscle pain
	Rheumatic pain
	Rheumatic pains
	Myofascial syndrome
	Fibromyalgia
M79.2 Neuralgia and neuritis, unspecified	Pain syndrome with neuralgia
	Brachialgia
	Occipital and intercostal neuralgia
	Neuralgia
	Neuralgic pain
	Neuralgia
	Neuralgia of the intercostal nerves
	Neuralgia of the posterior tibial nerve
	Neuritis
	Traumatic neuritis
	Neuritis
	Neurological pain syndromes
	Neurological contractures with spasms
	Acute neuritis
	Peripheral neuritis
	Post-traumatic neuralgia
	Severe neurogenic pain
	Chronic neuritis
	Essential neuralgia
R50 Fever of unknown origin	Hyperthermia malignant
	Malignant hyperthermia
R51 Headache	Head pain
	Pain due to sinusitis
	Pain in the back of the head
	Headache
	Headache of vasomotor origin
	Headache of vasomotor origin
	Headache with vasomotor disturbances
	Headache
	Neurological headache
	Serial headache
	Cephalgia
T14.3 Dislocation, sprain and damage to the capsular-ligamentous apparatus of a joint of an unspecified area of ​​the body	Painful muscle strains
	Pain and inflammation when stretched
	Reduction of dislocation
	Degenerative changes in the ligamentous apparatus
	Swelling due to sprains and bruises
	Swelling after interventions for dislocations
	Damage and rupture of ligaments
	Damage to the musculo-ligamentous apparatus
	Ligament damage
	Joint damage
	Habitual sprains and tears
	Ligament rupture
	Ligament tears
	Tendon ruptures
	Muscle tendon ruptures
	Joint injuries
	Stretching
	Crick
	Muscle strain
	Sprain
	Ligament sprain
	Tendon sprain
	Sprains
	Muscle strains
	Sprains
	Ligament sprains
	Tendon sprains
	Musculo-ligamentous injury
	Joint injuries
	Injuries to capsuloarticular tissues
	Injuries of the osteoarticular system
	Ligament injuries
	Joint injuries
T14.9 Injury, unspecified	Pain syndrome after injuries
	Pain syndrome due to injuries
	Pain syndrome during injuries and after surgery
	Pain from injuries
	Traumatic pain
	Joint pain due to injury
	Postoperative and post-traumatic pain
	Pain from injuries
	Pain of traumatic origin
	Severe pain syndrome of traumatic origin
	Deep tissue damage
	Deep scratches on the body
	Closed injury
	Minor domestic injuries
	Minor skin damage
	Violations of the integrity of soft tissues
	Uncomplicated injuries
	Extensive traumatic injury
	Acute pain syndrome of traumatic origin
	Swelling due to injuries
	Previous sports injuries
	Post-traumatic pain
	Soft tissue injuries
	Joint injuries
	Sports injuries
	Injury
	Traumatic pain
	Traumatic pain
	Traumatic infiltration
	Sports injuries

Ibufen is a modern analgesic with a high antipyretic and anti-inflammatory effect. The main active ingredient is ibuprofen, which belongs to the group of non-narcotic analgesic drugs.

Considering the mechanism of action of the drug "Ibufen", we can note the effective inhibition of prostaglandins, leading to a rapid decrease in the acute inflammatory process in the body, a decrease in the generation of nerve impulses (reduction of pain), as well as normalization of the temperature of the human body. The active influence on the synthesis of prostaglandins is carried out due to the inhibition of cyclooxygenase (enzyme), which plays a leading role in the metabolism of arachidonic acid with the subsequent formation of prostaglandins.

Today, the drugs Ibufen and Ibufen d are presented on the Russian market. The medicine with the letter “D” has similar properties and pharmacological effects to the classic medicine, but it is recommended for use in children over 3 years of age.

After application (orally), after 30 minutes, an antipyretic effect is observed, reaching its peak within three hours from the moment of administration. After oral administration, when it enters the stomach/intestines, the product demonstrates excellent absorption properties. The maximum concentration of the drug is observed 1-2 hours after active administration. For the active substance, there is the highest degree of plasma-protein binding.

The place of concentration of active substances is the liver, and is excreted by the kidneys, both in the form of metabolites and unchanged. Complete elimination from the body can be observed after 24 hours, and half-life is observed within 2 hours. There is no accumulation of the substance in the body. The product is recognized as highly effective and is used for a wide range of diseases. Ibufen, the price of which is about 100 rubles, is a medicine in the budget segment.

The instructions for use of Ibufen say that it is used for complex therapy of a wide range of diseases, including: influenza, acute respiratory diseases, viral infections. The drug can be used in pediatric practice, and it is recommended to use the analogue for children, Ibufen D. It has excellent pain-relieving properties and is also used to relieve joint pain and teething pain in children and adults.

The instructions for use of Ibufen say that the drug is taken orally. Before taking it, it is recommended to thoroughly shake the contents in the bottle until a homogeneous suspension is visible. In order to significantly reduce the possible risks of side effects of ibufen, it is recommended to take the drug 5-10 minutes after eating. When using Ibufen, there is no indication for dilution with water, but if necessary, you can drink the suspension. The kit comes with a special dispenser with which you can measure the required dose. In this case, the dose is prescribed individually, taking into account medical indications established by a qualified specialist. For maximum effect, it is recommended to divide the daily volume into 3-4 doses with an interval of at least 4 hours. 5 ml of Ibufen contains 100 mg of the active substance "ibuprofen".

If after use, body temperature remains at the same level or increases, you must urgently contact a doctor who has the necessary knowledge and skills to solve the problem. In some cases, a decision is made to adjust the existing treatment regimen.

Today, in addition to the classic version, Ibufen D is produced with instructions for use for children and parents. The drug is developed for children from 3 years of age and adolescents - used for complex therapy: acute and chronic toothache, serious and minor injuries of the musculoskeletal system, influenza, migraine, teething disease, respiratory diseases, inflammation of the middle ear, pharyngitis, post-vaccination reactions and other diseases in which there are symptoms of inflammation and fever.

Side effects of Ibufen

In most cases, the drug does not cause any side effects, but in some rare cases it can contribute to the active development of the following side effects:

1. The cardiovascular system. Cardiac dysfunction, thrombocytopenia, increased blood pressure, pancytopenia, agranulocytosis, and anemic phenomena may occur.
2. Gastrointestinal tract. In some cases, liver. Violation of healthy digestion, flatulence, bleeding from the gastrointestinal tract, stool disorders (diarrhea), acute gastritis, duodenal ulcer and similar phenomena.
3. Urinary system. Acute renal dysfunction, oliguria, hypernatremia, edema.
4. CNS. Severe headaches, fatigue, emotional lability, dizziness, sleep disturbances, tinnitus.
5. Allergic reactions: Stevens-Johnson syndrome, Quincke's edema, itching, Leyle's syndrome, skin rash, bronchospasm, anaphylactic shock.

Ibufen contraindications

Ibufen is strictly not recommended for use in case of individual sensitivity to all or any one component of the drug. It is strictly contraindicated in patients who have the “aspirin triad”, as well as in patients with acute galactose-glucose malabsorption disorder. Also, it is not recommended for people with a tendency to bleeding, poor blood clotting, and impaired renal and liver function.

Ibufen for children

Ibufen for children is an excellent modern drug with a wide spectrum of action, produced specifically for small and middle-aged children.

In the instructions for use of Ibufen syrup for children, you can find a detailed description of children's ages and dosage used at different ages of children and adolescents. Thus, a single dose of the children's drug is from 5 to 10 mg per 1 kg of weight. The maximum daily dose, in emergency cases, can reach 20-30 mg per 1 kg. Before giving the product to your child, it is recommended to warm it to room temperature and shake the bottle until a uniform suspension is formed. The dose is measured depending on the body weight and age of the child, and is administered orally. After which, if necessary, you can drink it with water at room temperature.

Regimen for taking Ibufen d for children of different ages:

1. 10-12 years - no more than 3 times 15 ml per day or 900 mg of active substance per day;
2. 7-9 years – no more than 3 times 10 ml per day or 600 mg of active substance per day;
3. 4-6 years - no more than 3 times a day, 7.5 ml or 450 mg of active substance per day;
4. 1-3 years - no more than 3 times 5 ml or 300 mg of active substance per day;
5. 6-12 months - no more than 3 times 2.5 ml or 150 mg of active ingredient per day.

Need to know!

Ibufen sold for children, reviews of which can be found on almost any pharmaceutical forum, speak of its excellent antipyretic effect. However, almost nowhere is it indicated that the drug differs significantly from the classic paracetamol drugs, which place a higher burden on the body when used.

Children's medicine quickly and for a long time reduces inflammation in the joints, significantly facilitating movement and pain. But with regular, long-term use, the active ingredient of the drug can cause acute damage to the gastric mucosa, as well as contribute to the formation of bleeding and ulcers in the child’s gastrointestinal tract.

During pregnancy or breastfeeding, the use of Ibufen is not recommended. If there is an urgent need to use the drug, it is necessary to undergo a detailed consultation with a qualified doctor.