What do utrozhestan 200 candles look like. Utrozhestan: what is it? How does progesterone affect the female body
Manufacturer: Laboratoires Besins International France
ATC code: G03DA04
Farm group:
Release form: Solid dosage forms. Vaginal capsules.
General characteristics. Compound:
Active substance: progesterone natural micronized 100 mg; 200 mg.
Excipients: peanut oil, soy lecithin, gelatin, glycerol, titanium dioxide.
Pharmacological properties:
progestational drug. Progesterone, the active substance of the drug Utrozhestan®, is a hormone of the corpus luteum. By binding to receptors on the surface of cells of target organs, it penetrates into the nucleus, where it activates DNA and stimulates RNA synthesis.
It promotes the transition of the uterine mucosa from the proliferation phase caused by the follicular hormone to the secretory phase. After fertilization, it contributes to the transition to the state necessary for the development of a fertilized egg. Reduces the excitability and contractility of the muscles of the uterus and fallopian tubes, stimulates the development of the terminal elements of the mammary gland.
By stimulating protein lipase, it increases fat reserves, increases glucose utilization. By increasing the concentration of basal and stimulated insulin, it contributes to the accumulation of glycogen in the liver, increases the production of gonadotropic hormones of the pituitary gland; reduces azotemia, increases the excretion of nitrogen in the urine.
Activates the growth of the secretory part of the acini of the mammary glands, induces lactation.
Promotes the formation of normal endometrium.
Pharmacokinetics. When taken orally. Suction. Micronized progesterone is absorbed from the gastrointestinal tract. The concentration of progesterone in the blood plasma gradually increases during the first hour, Cmax is observed 1-3 hours after ingestion.
The concentration of progesterone in the blood plasma increases from 0.13 ng / ml to 4.25 ng / ml after 1 hour, up to 11.75 ng / ml - after 2 hours and is 8.37 ng / ml after 3 hours, 2 ng / ml - after 6 hours and 1.64 ng / ml - 8 hours after administration.
Metabolism. The main metabolites that are determined in the blood plasma are 20-alpha-hydroxy-delta-4-alpha-pregnanolone and 5-alpha-dihydroprogesterone.
Withdrawal. It is excreted in the urine as metabolites, 95% of which are glucuron-conjugated metabolites, mainly 3-alpha, 5-beta-pregnanediol (pregnandione).
These metabolites, which are determined in blood plasma and urine, are similar to substances formed during the physiological secretion of the corpus luteum.
With intravaginal administration. Suction. Absorption occurs quickly, progesterone accumulates in the uterus. A high level of progesterone is observed 1 hour after administration. Cmax of progesterone in plasma is achieved 2-6 hours after administration. With the introduction of the drug 100 mg 2 times / day. the average concentration remains at the level of 9.7 ng / ml for 24 hours.
When administered in doses of more than 200 mg / day. the concentration of progesterone corresponds to the first trimester of pregnancy.
Metabolism. It is metabolized with the formation of predominantly 3-alpha, 5-beta-pregnanediol. The level of 5-beta-pregnanolone in plasma does not increase.
Withdrawal. It is excreted in the urine as metabolites, the main part is 3-alpha, 5-beta-pregnanediol (pregnandione). This is confirmed by a constant increase in its concentration (Cmax 142 ng / ml after 6 hours).
Indications for use:
Progesterone-deficient conditions in women, including:
for oral administration
- due to luteal insufficiency;
- premenstrual tension syndrome;
— violations menstrual cycle due to a violation of ovulation or;
- fibrocystic;
- premenopause;
- hormone replacement therapy of menopause (in combination with estrogenic drugs).
for intravaginal administration
- hormone replacement therapy for progesterone deficiency with non-functioning (absent) ovaries (with egg donation);
- support of the luteal phase during preparation for in vitro fertilization;
- support of the luteal phase in a spontaneous or induced menstrual cycle;
- premature menopause;
- hormone replacement therapy (in combination with estrogenic drugs);
- infertility due to luteal insufficiency;
- prevention of habitual or due to progestin deficiency;
- prevention;
- prevention.
Important! Get to know the treatment
Dosage and administration:
The duration of therapy is set individually, depending on the clinical situation.
For oral administration
The drug should be taken orally with water. In most cases, with progesterone deficiency, the daily dose of Utrozhestan is 200-400 mg, divided into 2 doses (morning and evening).
In case of insufficiency of the luteal phase (premenstrual tension syndrome, menstrual irregularities, fibrocystic mastopathy, dysmenorrhea, premenopause), the daily dose of the drug is 200 or 400 mg for 10 days (usually from the 17th to the 26th day of the cycle).
With hormone replacement therapy in peri- and postmenopause while taking estrogens, Utrozhestan® is used at 200 mg / day. within 10-12 days.
For intravaginal administration
In the complete absence of progesterone in women with non-functioning (absent) ovaries (egg donation), the drug is administered intravaginally against the background of estrogen therapy at 200 mg / day. on the 13th and 14th days of the cycle, then - 100 mg 2 times / day. from the 15th to the 25th day of the cycle, from the 26th day and in the case of determining pregnancy, the dose increases by 100 mg / day. every week, reaching a maximum (600 mg / day), divided into 3 injections. This dose is usually applied for 60 days.
To maintain the luteal phase during the in vitro fertilization cycle, it is recommended to administer intravaginally from 200 to 600 mg / day, starting from the day of injection of chorionic gonadotropin during the first and second trimesters of pregnancy.
To maintain the luteal phase in a spontaneous or induced menstrual cycle, with infertility associated with impaired function of the corpus luteum, it is recommended to administer intravaginally at 200-300 mg / day, starting from the 17th day of the cycle for 10 days, in case of delayed menstruation and diagnosis of pregnancy treatment should be continued.
In cases of a threatened abortion or in order to prevent habitual abortions that occur against the background of progesterone deficiency, 200-400 mg are administered intravaginally daily in 2 doses (morning and evening) in the I and II trimesters of pregnancy. The capsules are inserted deep into the vagina.
Application Features:
Utrozhestan® can not be used for contraception.
Influence on the ability to drive vehicles and control mechanisms
When taking the drug inside, care should be taken when engaging in potentially hazardous activities that require increased attention and speed of psychomotor reactions.
Side effects:
Allergic reactions.
When taken orally - drowsiness, transient (1-3 hours after taking the drug), extremely rarely - intermenstrual bleeding.
Interaction with other drugs:
When used together, Utrozhestan® enhances the effect of diuretics, antihypertensive medicines, immunosuppressants, anticoagulants. Reduces the lactogenic effect of oxytocin.
Contraindications:
- hypersensitivity to the components of the drug, incl. to peanut butter, soy;
- tendency to thrombosis;
- acute, hyperlipoproteinemia, during lactation.
The use of the drug UTROZHESTAN® during pregnancy and lactation
Utrozhestan® is indicated for use in the I and II trimesters of pregnancy.
Caution should be used during pregnancy (due to the risk of occurrence) and during lactation.
Application for violations of liver function
The use of the drug in porphyria, severe liver dysfunction (for oral administration) is contraindicated.
Application for violations of kidney function
The drug is used with caution in chronic renal failure.
Overdose:
Side effects most often indicate an overdose and disappear spontaneously with a decrease in the dose of the drug.
Storage conditions:
List B. The drug should be stored out of the reach of children at a temperature not exceeding 25 ° C.
Leave conditions:
On prescription
Package:
Capsules 100 mg - 30 pieces in a blister.
Capsules of 200 mg - 14 pieces in a blister. Oval-shaped capsules, with a shiny surface, yellowish color. Inside the capsules - a homogeneous oily suspension of white color without visible phase separation. The blister is packed in a cardboard box.
Utrozhestan belongs to the group of preparations-sources of the female hormone progesterone. His task is to help a woman carry a baby. However, it is prescribed not only to those who have a threat of miscarriage.
Utrozhestan during pregnancy
Modern gynecologists are very fond of prescribing this drug or its analogues. Bad ecology and a frantic pace of life weaken us, and even the most, at first glance, healthy women have situations when it is necessary to support the body hormonally. Progesterone preparations help a pregnant woman to spend months in anticipation of a baby without unnecessary risks.
Release form, composition, mechanism of action
Utrogestan is available in the form of capsules, depending on the dosage, they can be round (100mg) or oval (200mg). Capsules are soft to the touch, because. have a gelatinous shell, and inside them is a liquid substance. They can be both drunk and inserted into the vagina according to the principle of candles.
The active substance is progesterone. Usually, a plant-derived hormone is used, a complete analogue of the female sex hormone. Once in the blood, it binds to receptors on the surface of the "target" organs (uterus and ovaries) and penetrates into the nuclei of their cells. It helps the uterus reach the state that is necessary for the proper development of a fertilized egg. It becomes soft, does not shrink, which allows the egg to firmly attach and receive nutrition. In addition, progesterone suppresses ovulation, promotes the development of mammary glands, helps the expectant mother to accumulate fat (yes, and this is laid down by nature in order to safely bear a baby).
At the stage of pregnancy planning, Utrozhestan helps to form a thick mucous membrane (endometrium) on the uterus, which will allow the egg, if it is fertilized, to attach to the uterus and begin development.
Use in early and late pregnancy
Official instruction to the drug says that pregnant women need to take Utrozhestan in the I and II trimesters of pregnancy. This is due to the fact that progesterone deficiency can only occur when the placenta is not fully formed. At 16–20 weeks, the placenta is fully formed and provides the baby with hormones. Taking progesterone supplements after 20 weeks is considered by many to be pointless.
However, each case is individual, and there are women for whom doctors extend the drug to 34–35 weeks, mainly due to increased uterine tone.
An analysis for the level of progesterone is done at the beginning of pregnancy - according to its results, a decision is made on the appointment of the drug The question here is only trust in the doctor. I once had to put Utrozhestan up to 27 weeks. I believe that I would have used it to the very end if I had not raised the issue of stopping the reception. The pregnancy proceeded calmly, and it seemed that there was no point in spending money on an expensive drug, which, moreover, had to be taken regularly without missing a single capsule (this meant regular trips to the pharmacy and endless search for discounts).
Objectively: there are other drugs with a different mechanism of action aimed at maintaining pregnancy in the third trimester, for example, Ginipral. It prevents excessive tone. However, the issue of stopping Utrozhestan or switching to other medicines should be discussed only with your doctor! Utrozhestan does not have any effect on the fetus, so you should not be afraid to take it if the doctor insists on this and gives valuable arguments.
Indications, contraindications, side effects
Pregnant women are prescribed Utrozhestan for:
- the threat of abortion or if the woman has had abortions before;
- the existing threat of premature birth (when the period has not yet come, and the cervix has begun to shorten);
- increased tone of the uterus.
My doctor prescribed this drug to me after an ultrasound at 7-8 weeks of pregnancy. The reason was the discovered cyst of the corpus luteum (as a result, a possible violation of the production of progesterone). In addition, the gynecologist drew attention to the insufficiently good attachment of the fetal egg to the walls of the uterus. The doctor immediately predicted that Utrozhestan would have to be drunk until the middle of the second trimester. In addition to taking hormones, motor rest was prescribed at least until the first screening. 
To survive, the embryo must literally "grow" into the endometrium, and this requires progesterone
Women planning a pregnancy and those who have been diagnosed with infertility, in preparation for the IVF procedure Utrozhestan, are prescribed:
- to support the luteal phase (this helps the egg, if fertilized, to gain a foothold in the uterus);
- as hormone replacement therapy if the body does not produce enough progesterone.
In addition, Utrozhestan softens the moment of menopause, improves the quality of life of women who, for some reason, have had their ovaries removed.
Contraindications to the use of Utrozhestan are:
- thrombosis and thromboembolic disorders;
- bleeding from the vagina with an unknown cause;
- the presence or suspicion of malignant tumors of the breast or genital organs;
- porphyria;
- incomplete abortion;
- liver disease;
- under 18 years of age (no studies have been conducted);
- breastfeeding (passes into breast milk);
- allergic reactions to the components of the drug (especially soy lecithin).
Like any hormonal drug, Utrozhestan has side effects. If the side effects make themselves felt too much, then you should talk with your doctor about reducing the dosage.
Women taking this drug may experience:
- drowsiness, dizziness;
- menstrual disorders, spotting discharge outside of menstruation;
- headache;
- nausea, bloating, constipation or diarrhea;
- skin rashes, itching.
If the side effects are too severe, the doctor may recommend switching from oral to intravaginal: as mentioned above, the capsules can be used in both ways.
Features of the use of a hormonal drug
If the doctor has prescribed to take the drug 1 time per day, then it is best to drink / put the capsule at night, because. it can cause drowsiness. When taken orally, the capsule should be swallowed with a plain water. When inserting into the vagina, wash your hands and insert the capsule as deeply as possible.
Do not take Utrozhestan with food: food will make it difficult for progesterone to be absorbed!
Doses and regimen of the drug is prescribed only by a doctor! Taking the drug in pregnant women and those who only dream of conceiving a baby will greatly differ in the number of capsules per day, the duration of treatment. The manufacturer of the medicine recommends taking 100-200 mg of the drug at a time and not going beyond daily allowance in 600 mg.
Depending on the goals and condition of the woman, the doctor may prescribe a regimen of 2 or 3 doses per day. It is not necessary that the doses in the morning and in the evening will be equal: 200 mg at night and 100 mg in the morning are often prescribed to avoid weakness. The dose can be maintenance, only 100 mg - it all depends on the results of the diagnosis. Therefore, first of all, you should focus on the doctor's recommendations, because. The abstract describes only general principles treatment.
The duration of the course will also be determined by the gynecologist. The official instructions prescribe the use of the drug until the end of the second trimester. For those planning a pregnancy, the course of administration is usually shorter: it lasts 10 days, starting from the 17th day of the cycle.
Like any other hormonal drug, Utrozhestan should be taken exactly according to the scheme and preferably at the same time. It should be canceled smoothly: within a week, the dosage is halved (that is, the amount of the substance is reduced), then the same amount is taken once a day, then every other day, and then reduced to nothing. The withdrawal scheme should also be described by the doctor. 
A pill box or a special application on your phone will help you not to miss taking the capsule
It is undesirable to skip taking the pills. In my practice, there was a case when the pack ran out, and a new one had not yet been bought, and I had to skip evening reception. There were no consequences from this, although extra nerves were spent. There are situations when the drug disappears from pharmacies due to supply interruptions. Given all this, it makes sense to purchase Utrozhestan with a margin: anyway, the drug is not abruptly canceled, which means it will most likely be used up.
The drug progesterone actively interacts with other drugs. If a woman has to take more and other pills, you should definitely consult a doctor.
Photo gallery: what drugs do not combine with Utrozhestan
Tetracycline and penicillin antibiotics reduce the effectiveness of Utrogestan Utrogestan enhances the effect of drugs that reduce blood pressure Utrogestan enhances the effect of diuretics (diuretics) Utrogestan may increase the need for insulin in diabetic patients
Analogues of Utrozhestan - other means based on progesterone
Utrozhestan has analogues. It is interesting that among all these drugs there are no obviously cheap ones, that is, it will not work to save a lot by taking an analogue. However, a substitute drug can help out if the main one is not on sale. Before taking an analogue, you must always consult a doctor!
Table: analogues of Utrozhestan and their features
| A drug | Release form | Compound | Peculiarities |
| Duphaston | Coated tablets are available in packs of 20 or 28. | Dydrogesterone (analogous to progesterone) 10 mg, excipients. | To maintain the proper level of progesterone, pregnant women are advised to take 1 tablet 2 times a day, however, the scheme is prescribed by the doctor in each case. The drug is in many ways similar to Utrozhestan. However, among the side effects, the manufacturer does not indicate drowsiness, and also writes that "the drug does not affect the ability to drive vehicles and other mechanisms." For many women, this can be important. |
| Prajisan | Capsules, pack of 10 pieces. | Progesterone 200 mg, excipients. | As with Utrozhestan, this drug can be taken either orally or intravaginally. The dosage recommended by the manufacturer for pregnant women is 200-400 mg 2 times a day. |
| Iprozhin | Capsules, pack of 15 or 30 pieces | Progesterone micronized 100 mg, excipients. | It can be taken with water or injected into the vagina. For the prevention of miscarriage, a dose of 100-200 mg twice a day is recommended for pregnant women. The duration of treatment is determined by the doctor. |
| Crinon | Gel for intravaginal application. Each dose is packaged in a separate disposable vial. | Progesterone, 90 mg per dose, excipients. | Recommended for use in pregnancy planning. Pregnant women are allowed only if the pregnancy occurred as a result of IVF and the gel has already been used in preparation for the procedure. In this case, it is used only on the most early dates expectations. |
Indications for use
Utrozhestan is a progesterone drug. It is used for conditions associated with a lack of progesterone, including: premenstrual syndrome, dysmenorrhea, fibrocystic mastopathy, premenopause and menopause.
Composition and form of release:
Utrozhestan capsules 14 or 30 pcs. packaged.
1 capsule Utrozhestan contains: natural micronized progesterone 100 or 200 mg.
Indications for the use of Utrozhestan:
Utrozhestan is used for disorders associated with a lack of progesterone:
Ingestion:
- endocrine infertility;
- prevention of habitual miscarriage or the threat of miscarriage on the background of luteal insufficiency;
- the threat of premature birth;
- premenstrual syndrome;
- menstrual irregularities;
- fibrocystic mastopathy, mastalgia;
- hormone replacement therapy in case of progesterone deficiency with non-functioning / absent ovaries;
- luteal phase support during preparation for in vitro fertilization;
- support of the luteal phase in a spontaneous or induced menstrual cycle;
- premature menopause;
- premenopause, menopause, postmenopause - hormone replacement therapy in combination with estrogenic drugs;
- endocrine infertility;
Contraindications for use
- hypersensitivity to the components of Utrozhestan;
- vaginal bleeding of unknown etiology;
- incomplete abortion;
- porphyria;
- malignant neoplasms of the mammary glands or genital organs.
- tendency to thrombosis;
- acute phlebitis or thromboembolism;
- severe liver disease, liver failure.
Use in pregnancy and children
Utrozhestan is indicated for use in the I and II trimesters of pregnancy. Use with caution in the III trimester of pregnancy and lactation. In clinical studies, no adverse effects on the fetus were observed during the period of Utrogestan use. In the II and III trimesters of pregnancy, monitoring of liver function is necessary.
Progesterone passes into breast milk in small amounts, so Utrogestan should be avoided during breastfeeding.
Side effects
Side effects are usually observed when Utrozhestan is taken orally.
From the nervous system: drowsiness, transient dizziness, especially in the case of concomitant hypoestrogenism. Reducing the dose of Utrozhestan or increasing the dose of estrogen eliminates these phenomena without reducing the therapeutic effect.
From the reproductive system: reduction of the cycle, intermenstrual spotting.
Utrozhestan is medicinal product, which is based on the hormone progesterone. It should be noted that a certain amount of this substance is needed for an adequate pregnancy.
That is why Utrozhestan actively uses the branch of obstetrics and gynecology.
In order to understand how the drug works, you need to understand how natural progesterone acts on the body of the expectant mother.
Why is Utrozhestan prescribed for those who are planning a pregnancy
In the body of a woman, the hormone we are talking about is synthesized by several organs. This connection is often defined as pregnancy hormone, because in its normal level, progesterone indicates that ovulation is effective. Otherwise, fertilization simply cannot occur.
In pregnant women, the level of this hormone in the blood increases significantly. The reason for this is the functioning of the placenta. It is the normal amount of progesterone that is one of the most important factors successful pregnancy.
Progesterone begins to act expressly already when the inner lining of the uterus is preparing to fix the egg after the latter has been fertilized. Progesterone finishes acting only at the very end of pregnancy before the expected date of the baby's birth.
Candles Utrozhestan, in fact, have only one indication - lack of progesterone in the female body. But different expressions of this are possible: a cyst, an endometrium, as well as hyperandrogenism, manifested by skin rashes and active hair growth, which is not characteristic of a woman in a normal state.
For those who want to become parents in the near future, the drug Utrozhestan can be prescribed in three situations:
- A decrease in progesterone in the blood, for which there are no special symptoms. This phenomenon is not so rare, and it is dangerous both when pregnancy has occurred and at the time of its planning, since the likelihood of conception is significantly reduced. It is possible to continue using the drug after, during gestation, if there is a risk of miscarriage in the early stages or premature birth. Utrozhestan is often used in the first few weeks of pregnancy.
- Infertility caused by a lack of progesterone.
- A miscarriage resulting from a hormonal imbalance, expressed in a decrease in the amount of specifically progesterone.
To understand that the use of the drug is really necessary, you need to conduct a study in the laboratory. It is important to take into account day of the menstrual cycle, since progesterone tests are usually recommended to be carried out in the second part of the cycle.
Utrozhestan can completely replace natural progesterone, as it has a completely similar molecular structure. The difference from the hormone itself is that the drug is entirely, one hundred percent, absorbed by the intestines.
Utrozhestan is the only currently existing analogue of the hormone progesterone of plant origin. Therefore, in comparison with chemically synthesized hormone analogs, it has fewer side effects, and their risk is also lower. The fact that the progesterone molecules in Utrozhestan are surrounded by peanut butter helps to improve the absorption of the drug in the digestive tract.
The drug helps prepare the female body to pregnancy, as it helps to ensure the growth of the endometrium. In fact, it affects the body in the same way as progesterone itself. The endometrium swells, it gets a loosened structure, which helps the egg after fertilization to implant and gain a foothold on the wall of the uterus.
At the same time, the drug does not allow an increase in estrogen in the second phase of the cycle. It can increase body temperature and provide nervous relaxation. That is, the body thanks to Utrozhestan preparing for conception, since it has all the functions of a natural hubbub, and the right prerequisites are created in the body, both for the onset of pregnancy and its correct course in the first half.
Utrozhestan reduces the tone of the uterus. This makes it possible to ensure the harmonious development of the fetus in the first weeks of variability. The risk of miscarriage also becomes lower. Taking Utrozhestan, ladies may not be afraid to get better, since the drug is not able to retain fluid in the body and take part in fat and carbohydrate metabolism.
So, we can safely say - very a worthy analogue of natural progesterone. And women whose hormonal balance is disturbed for one reason or another have a high chance of becoming pregnant, bearing and giving birth to a healthy baby.
Utrozhestan during pregnancy
Cases of miscarriages are now not so rare, which is facilitated by modern environmental problems, mistakes in the lifestyle of pregnant women, from bad habits. Sometimes the reasons may relate to a specific woman, sometimes they are global. Stress, conflicts, all kinds of infections have a negative impact - all this can have an extremely negative impact on how pregnancy proceeds.
Another very negative factor that belongs to narrower ones is lack of progesterone in the body. In the body of a pregnant woman, this hormone is also produced by the placenta. But in some cases, in the body of the expectant mother, there may be malfunctions in the production of progesterone and a decrease in the quality of the hormone.
This most often occurs during the most unsafe period of pregnancy - 8-12 weeks. Then the risk of miscarriage increases significantly. But this is not a reason to fall into despair, since modern medicine, thanks to such natural progesterone substitutes as Utrozhestan, helps to qualitatively solve the problem. hormonal disorders.
For pregnant women, vaginal use of Utrozhestan (in the form of suppositories) is recommended more often than tablets, since the substance is absorbed extremely quickly, not reaching the uterus. Therefore, candles are better tolerated by expectant mothers. The use of the drug is not dangerous for the expectant mother.
It does not replace natural hormones, but only increases their quantity. The drug works on improvement of the inner layer of the uterus known as the endometrium. It affects the uterus and its tubes, reduces the level of contractility and excitability of their muscles.
The drug can normally be combined with antispasmodics and sedatives. The ultimate goal is to help expectant mother give birth to a healthy baby on time, since there is no danger for the child himself.
Additional benefits for the expectant mother are that Utrozhestan does not increase weight, does not provoke swelling and does not affect blood pressure. However, since the drug is hormonal, it cannot do without contraindications.
So, it must be borne in mind that the drug cannot be prescribed to those pregnant women who are prone to thrombosis, thrombophlebitis. Among the obvious contraindications a diseased liver and the transfer of previously malignant tumors are isolated. For a number of other problems such as diabetes, asthma, problems of the nervous system, the specialist should be very careful when prescribing this medication for you
Also, the danger lies in taking the drug for all nine months. The fact is that it can accumulate in the liver and negatively affect its work. Because of this, taking Utrozhestan is usually canceled in the last trimester baby's expectations.
Instructions for use
There are two forms of the drug - capsules and vaginal suppositories. During the planning of conception, the dose of the drug in the form of capsules, as a rule, is 200-300 mg. The volume should be divided by two and consumed in the morning and evening.
Mostly capsules are used for 16-25 days of the cycle with a course of 10-12 days. Capsules are taken orally, not chewed and washed down with water. The dosage will be similar if Utrozhestan is prescribed for infertility, which was caused by a lack of progesterone in a woman.
Candles Utrozhestan quickly absorbed into the blood, and they have fewer side effects, so they are often indicated for use. You need to enter them in a supine position, mostly experts recommend doing this at bedtime. Candles, after they have been introduced, dissolve slowly.
The maximum level of the hormone in the blood is reached at least 2 hours after direct administration. When applied twice a day, they act throughout the day. After the introduction of progesterone begins to rapidly accumulate in the uterus, the inner lining of which begins to work normally.
If a woman managed to get pregnant, specifically progesterone maintains the characteristics of the inner uterine membrane that are most convenient for the baby. It is important to insert suppositories through the vagina as deep as possible. This process will be facilitated by the use of the applicator.
The duration of the drug is regulated by the doctor. In most cases, pregnant women are prescribed Utrozhestan for the first three months. In certain situations, treatment must be extended up to twenty weeks. Here everything is determined by the presence or absence of various problems in the process of bearing a baby.
Despite the fact that Utrozhestan is not prohibited for pregnant women, in the third trimester it prescribe carefully and only in special occasions because there is a risk of further liver problems.
Contraindications and possible side effects
A woman who wants to become a mother should understand that, despite the fact that in many cases Utrozhestan is the same saving magic wand, the use of this drug is only allowed after appointment of a specialist.
Only he can identify those factors due to which a hormonal drug can be prohibited from taking. Moreover, in this case there is no difference what exactly it is about - Utrozhestan in tablets or in such a form of the drug as candles.
Contraindications to taking Utrozhestan may be as follows:
- noticeable and complicated course of varicose veins;
- the presence of thrombophlebitis;
- liver disease;
- certain types of transferred tumors.
Some states are considered undesirable. So, caution is needed for diabetes, bronchial asthma, problems with the heart, blood vessels.
Side effects Utrozhestan theoretically has, but they are rather an exception, since this happens very rarely. So, some women notice drowsiness and dizziness when taking Utrozhestan in the form of tablets, and they are very slightly expressed.
But do not forget about it if you are going to drive a car, because even a minimal slowdown in the reactions of the central nervous system can affect the control of the car.
Price
The cost of the drug depends on the pharmacy where you buy it and the city where this pharmacy is located. So, 28 capsules of Utrozhestan 100 mg will cost from 370 to 445 rubles. And 14 capsules of the drug 200 mg cost between 369-420 rubles.
Analogues
In accordance with the active substance, Utrozhestan has several analogues: Progesterone, Progestogel, Iprozhin, Duphaston. And often the choice is between Utrozhestan and Duphaston. Women are interested in how interchangeable they are, and which one is better. It is possible to distinguish such differences between these drugs:
- Utrozhestan contains natural micronized hormone progesterone. Dufaston also includes its analogue.
- Dufaston has its advantages. So, the drug can not cause allergic reactions and hormonal disorders. It has no negative effects in the form of dizziness, fatigue and constant drowsiness. In view of this, it does not affect driving skills and the ability to perform actions that require quick response.
- Duphaston is available only in the form of tablets, and Utrozhestan can be used both orally and as candles.
- When it comes to choosing a drug for breastfeeding woman, then preference is given to Duphaston, since it cannot be excreted with mother's milk.
The choice of a specific medication will be made exclusively by a doctor. In each case, this solution may be different. Possible contraindications and existing symptoms are taken into account. If Utrozhestan was prescribed to you by a doctor, you should not take another drug instead, as the result may be completely different. By itself, Utrozhestan is considered safe and effective, as evidenced by a number of positive reviews.
Candles Utrozhestan: reviews
The effectiveness of the drug is confirmed numerous reviews women who, thanks to him, were able to fulfill their long-awaited dream of motherhood.
Anna, Yekaterinburg: I had a failure of the second phase of the cycle, which is why ovulation did not occur. After passing the tests, it became clear that there was not enough progesterone in the body. The doctor recommended Utrozhestan, and already in the first cycle I was able to get pregnant!
Marina, Moscow: Not so long ago there was a miscarriage, and because of this, Utrozhestan was prescribed by a doctor. And pregnancy came very quickly. It turned out that the cause of the previous miscarriage was a lack of progesterone. Utrozhestan helped me become a mother this time.
Katerina, Tula:
They recommended Utrozhestan in the center where I was observed at that time. I noticed that sometimes I feel dizzy. I still don’t understand if it was a side effect of the drug or the result of excitement from the fact that everything could happen soon. Doctors advised me to do a test later, and it was positive! Nine months later, such a long-awaited daughter was born.
In addition to patient reviews, you should also read expert reviews, that is, doctors who prescribe this drug. Below are some of them:
Irina Mikhailovna: Utrozhestan - high performance drug, which I prescribe to those who are planning to conceive a child, relatively often. Those who used it under my guidance were able to prevent the development of numerous side effects. It is important to understand that the drug is hormonal, respectively, it has a certain connection with the work of the kidneys and liver. Therefore, I believe that women should not use it during pregnancy.
Viktor Petrovich:
Utrozhestan in tablets and suppositories helps make up for a deficiency progesterone, and the chances of getting pregnant because of this increase. During my practice, I have observed some side effects in patients when using the drug. So, it is possible to increase sweating, fever, toxicosis during further pregnancy. But the effectiveness of the drug from this does not decrease. The extent to which it is advisable to prescribe it is determined by the overall clinical picture and is decided individually in each case.
Vladimir Alekseevich: During my medical practice, I came across cases when it was Utrozhestan that became the salvation and will allow a woman finally get pregnant. And sometimes he became the cause of the appearance of very unpleasant symptoms. In each situation, everything is individual. I will never give a patient an appointment without a thorough examination. It is very important to strictly follow the prescriptions of the doctor and the scheme of using the drug determined by him. Only thanks to a very responsible approach to this hormonal remedy can the risk of side effects be reduced.
Thus, Utrozhestan - great opportunity for those who have not yet experienced the joy of motherhood due to problems with progesterone. Only a doctor can prescribe it, and when using it, be sure to follow all his recommendations.
Utrozhestan during pregnancy is prescribed for a lack of progesterone. Progesterone contributes to the development of pregnancy and is normally produced in sufficient quantities by the adrenal glands and the placenta.
With severe varicose veins and liver diseases, the drug is not prescribed. It prepares the body for conception without harming it. Available in both suppositories and capsules. Capsules are taken in the evening at a dosage of 200-300 mg, which must be divided into two times.
How does utrogestan affect pregnancy?
Utrozhestan during pregnancy helps the fetal egg to implant normally to the wall of the uterus and further supports its normal development into the embryo. Utrozhestan is a synthetic analogue of progesterone. It does not affect the child. With caution prescribed for varicose veins, diabetes and diseases of the central nervous system. The drug is gradually canceled within a month, reducing the dosage. The lack of progesterone often ends in infertility, but we have good news for you - now this problem can be completely solved! Just do not self-medicate, dear women, because pregnancy is a very delicate process, the slightest shift in hormonal levels can cause a miscarriage. Get your blood tested for progesterone before taking it.
Utrozhestan in early pregnancy
Utrozhestan during early pregnancy, in the first trimester, is prescribed mainly in the form of suppositories, which are administered at the same time in the evening every day. This form of the drug is preferable to tablets, since it causes fewer side effects that are undesirable for the pregnant woman and the baby, especially from the liver.
Medicine can solve many of the problems with pregnancy by giving women an adequate dose of progesterone. The drug reduces the tone of the uterus and puts in order the nervous system. Side effects of Utrozhestan during early pregnancy: dizziness and absent-mindedness, so be extremely careful when driving a car and at work. Thrombophlebitis, varicose veins and liver problems can also cause the doctor to refuse you Utrozhestan therapy. In most cases, Utrozhestan is well tolerated. Additional care is needed when taking the drug to pregnant women, those suffering from diabetes mellitus and having problems with cardiovascular system. There are no uniform recommendations for all pregnant women - a possible daily dosage is 300-600 mg. Because it is a plant-based product, you will not be able to gain weight while taking it. It does not take part in carbohydrate and lipid metabolism. Utrozhestan does not cause swelling and does not harm the baby, does not lead to hormonal disorders in the child after birth. This is evidenced by the fact that hundreds of thousands of children around the world were born due to the fact that the doctor recommended Utrozhestan with the threat of termination of pregnancy. The drug has no analogues.
Utrozhestan at 5 weeks pregnant
Pregnancy is a special state of the body, it is an occasion for joy and new hopes. But often during pregnancy, for a short period of time, it is necessary to prescribe drugs that help preserve it. Utrozhestan during pregnancy at 5 weeks you may be prescribed if there is a slight spotting or the uterus is in good shape. Utrozhestan is designed for long-term use. It is made on the basis of vegetable raw materials. So lowering the hormonal background should not cause you to panic, it can be completely eliminated without consequences for your health during pregnancy. But self-medication should not be done in any case - everything is under the control of a gynecologist!
The drug has a minimum of side effects, while taking it, you will not suffer from edema or gain weight. It normalizes the structure of the endometrium in early pregnancy so that it is good for the baby to be in your stomach.
You can not abruptly cancel the drug. Your doctor will tell you at your appointment how best to reduce your dosage. Usually weekly it is reduced by 50 mg.
Utrozhestan at 13 weeks pregnant
Utrozhestan at the 13th week of pregnancy is prescribed if there is a threat of termination of pregnancy due to a lack of progesterone. This problem is very common today. Antispasmodics are also often prescribed. They are fully compatible with Utrozhestan. Utrozhestan during pregnancy in most cases is prescribed at a dosage of 200 mg. Utrozhestan does not suppress the production of pregnancy hormones by your body, but complements them and therefore cannot harm. The only thing to consider is that utrozhestan should not be prescribed to women with liver problems, thrombosis and varicose veins.
Utrozhestan in late pregnancy
Utrozhestan during late pregnancy can be used if there is an underdevelopment of the placenta. If there is a chronic habitual miscarriage, the doctor can play it safe and prescribe it to you after the 20th week and almost until the very birth. Also, Utrozhestan in the later stages is shown to those mothers who underwent IVF. It is preferable to use candles - they do not act on the liver. You can not worry - the drug does not harm the fetus.
Utrozhestan after 20 weeks of pregnancy
Utrozhestan during pregnancy after a period of 20 weeks is rarely prescribed, since hormonal support after this period actually loses its significance. But it happens that, according to the results of blood tests, there is still not enough progesterone, even taking into account the one that the placenta begins to produce at week 20. In this case, it may be necessary to drink Utrozhestan before childbirth. Also, the problem may be relevant if the pregnancy occurred as a result of artificial insemination and in women with isthmic-cervical insufficiency.
Utrozhestan at 22 weeks pregnant
Utrozhestan during pregnancy at week 22 is prescribed for shortening of the cervix, as this can cause premature birth due to the threat of its early disclosure. If there was a history of miscarriages, miscarriages or premature births, the doctor may also prescribe Utrozhestan to insure. There is nothing wrong with this. Strictly follow his recommendations and when the time comes, cancel the drug according to the prescribed scheme. It will definitely help you give birth to a healthy baby on time, without bringing him any harm, since it contains a plant analogue of progesterone.
Utrozhestan at 30 weeks pregnant
Utrozhestan at the 30th week of pregnancy is prescribed for a short soft cervix and if the child is located low in the uterine cavity. If the doctor prescribes you Utrozhestan for such a period, then he has reason to do so, so you should not refuse - it can be dangerous for the baby. Of course, the drug is mainly used in the early stages, but each clinical case is completely individual. Trust the experts.
Duphaston or utrogestan during pregnancy: which is better?
Progesterone is a pregnancy hormone produced by the placenta and adrenal glands. Both drugs are designed to compensate for the lack of progesterone in a woman's body. Placental insufficiency is one of the most common causes of miscarriages.
The difference is that Utrozhestan is a natural analogue of progesterone, and Duphaston is a synthetic progesterone. But the experience of using Duphaston is longer, which can be attributed to the pluses.
Both Duphaston and Utrozhestan relieve increased uterine tone during pregnancy.
Utrozhestan has a mild sedative effect.
Duphaston is a much stronger drug. As a rule, it is prescribed in a dosage of 1-4 tabs up to 18 weeks. Contraindications: asthma, diabetes.
Instructions for use utrozhestan during pregnancy
Utrozhestan during pregnancy is taken orally or intravaginally. The usual dosage of tablets is 200 mg. The drug is taken in two doses.
200 mg of the drug is injected into the vagina in two divided doses, preferably at night, as it tends to leak out.
Utrozhestan is carefully used for diabetes mellitus, epilepsy, depression, varicose veins, thrombosis, for liver problems not in the stage of compensation, for malignant neoplasms of the female genital area and mammary glands at the time of admission, or in history.
When taking the drug, drowsiness and absent-mindedness are possible. Be careful when driving.
Utrozhestan during pregnancy is prescribed today by gynecologists quite often. However, care must be taken when using progesterone during pregnancy, self-medication is unacceptable. In some European countries, Utrozhestan is not used. This is due to the fact that its effect on the fetus is still little studied. The drug is new. In what cases is the drug justified:
- If a lack of progesterone is detected in the laboratory in a blood test during pregnancy.
- If you have recurrent miscarriage associated with a lack of progesterone.
- If you are unable to conceive due to a lack of progesterone.
Be sure to keep in mind that the dosage and duration of treatment with Utrozhestan is set only by a doctor! Usually a dose of 200-300 mg is administered twice. Cancellation of the drug is carried out gradually. The withdrawal plan is prescribed by the doctor. Usually, each week is administered 100 mg less than the previous one until completely cancelled. Abrupt cancellation can provoke a miscarriage!
How much to take utrogestan during pregnancy?
Utrozhestan during pregnancy provides the expectant mother with effective hormonal support. It is prescribed if there is a threat of miscarriage before the 24th week of pregnancy. In women with liver problems, it is preferable to use Utrozhestan suppositories.
Cancellation of utrogestan during pregnancy
Utrozhestan is canceled during pregnancy, reducing the dose by 100 mg per week, or by 50 mg every three days. At the same time, make sure that there is no bleeding from the genital tract. In any case, cancel Utrozhestan gradually, so as not to harm the child.
Discharge after utrogestan during pregnancy
Discharge after the introduction of Utrozhestan suppositories during pregnancy should not bother you, as they melt into the vagina and flow out. White discharge is the norm in this case.
Bloody discharge requires dose adjustment of the drug. If you find a spot on your underwear, go to an emergency appointment with an obstetrician-gynecologist!
Pregnancy after taking utrogestan
The desired pregnancy sometimes does not occur due to progesterone deficiency. Utrozhestan during pregnancy and at the planning stage in the form of capsules and suppositories copes with this problem. He helped thousands of women get pregnant and give birth to a healthy child. To be safe, at the planning stage, the doctor may prescribe Utrozhestan to women with acne or male-type hair. You can not prescribe the drug yourself. Taking Utrozhestan causes dizziness and drowsiness in some women.
Taking utrogestan during a missed pregnancy
Utrozhestan during pregnancy can be prescribed after a frozen pregnancy, especially if there are alarming symptoms, for example, brown discharge. The progesterone contained in the preparation will help you carry your pregnancy. Utrozhestan tablet or suppositories are drunk or administered in the morning and evening. Usually the dosage is 200-300 mg per day, but if the threat is very strong and the hormonal dysfunction is pronounced according to the analyzes, the dose can be increased to 600 mg per day.
Dose of utrogestan during pregnancy
Utrozhestan during pregnancy, if there is a lack of progesterone, is prescribed 200-300 mg in the morning and evening orally or intravaginally. The method of application is chosen by the doctor, taking into account your individual characteristics.
With IVF and habitual miscarriage, the gynecologist can increase the dosage to 800 mg (also in two doses). In this case, therapy is continued until 24-26 weeks of pregnancy.
Utrozhestan 100 during pregnancy
Utrozhestan during pregnancy is used in the form of capsules of 100 and 200 mg. Different dosage allows you to individually approach the appointment of the drug to each patient. It has been proven that the intravaginal administration of a capsule in case of a threatened miscarriage is more effective and safe than taking the tablets inside. This minimizes side effects and does not harm the liver.
Utrozhestan is carefully used for problems with the functioning of the kidneys and liver, varicose veins, diabetes mellitus and epilepsy.
Utrozhestan 200 during pregnancy
Progesterone, even during the menstrual cycle, when there is no pregnancy, prepares the body for the possible attachment of a fertilized egg. It is produced by the corpus luteum. The corpus luteum arises at the site of a burst follicle with an egg and is a temporary endocrine gland.
Basically, the drug Utrozhestan 200, containing a plant analogue of progesterone, is prescribed in the first 24 weeks of pregnancy, and then the reception is stopped, as it begins to accumulate in the liver and negatively affect its function.
Contraindications to taking the drug Utrozhestan during pregnancy: diabetes mellitus, epilepsy, depression, varicose veins, severe liver dysfunction, tumors of the female genital organs and mammary glands.
],Candles utrozhestan during pregnancy
Progesterone helps the fertilized egg to fully develop. But sometimes it happens that a woman in the body does not have enough of it. And then the pregnancy either cannot occur at all, or it occurs, but is interrupted, ending in a miscarriage. In this case, during the next pregnancy, the doctor insists on taking progesterone. Given that pregnancy and medication are not compatible, it is necessary to minimize all side effects and to spare the liver working for two as much as possible, the gynecologist may prescribe you not pills, but vaginal suppositories, for example, Utrozhestan.
The industry produces candles of 100 mg and 200 mg. The drug in the form of vaginal suppositories is very quickly absorbed into the blood, bypassing the liver. Utrozhestan is wonderfully combined with vitamin complexes for pregnant women and sedatives. Cancellation of the drug is carried out in the II trimester, gradually reducing the dose. Abrupt cancellation of the drug Utrozhestan during pregnancy is unacceptable.
Utrozhestan tablets during pregnancy
In our time, the problem of miscarriages is very relevant. Only 80% of pregnancies end in childbirth. Women's health is most affected by stress and STDs. A gynecologist may prescribe Utrozhestan tablets to a pregnant woman if these negative factors have affected her hormonal background and her progesterone levels dropped. Utrozhestan during pregnancy is also used in the form of suppositories, but the doctor may decide in some cases that the form of tablets is more suitable for a particular pregnant woman. This drug reduces the contraction of the uterus and fallopian tubes. The drug complements the hormones that the female body produces. An excess of progesterone during its use is impossible. And yet, there are a number of contraindications: thrombosis, malignant tumors of the female genital organs, severe liver disease, leading to a severe violation of its function.
