Fenkarol 10 tablets instructions for use. Fenkarol - instructions for use
Active substance
Quifenadine hydrochloride
Release form, composition and packaging
◊ Pills white or almost white, round, flat-cylindrical, with a chamfer and a notch.
Excipients: potato starch - 14.5 mg, sucrose - 25 mg, calcium stearate - 0.5 mg.
◊ Pills
Excipients: potato starch - 40.5 mg, sucrose - 33.5 mg, calcium stearate - 1 mg.
10 pieces. - contour cell packaging (2) - cardboard packs.
◊ Pills white or almost white, round, flat-cylindrical, chamfered.
Excipients: potato starch - 74 mg, sucrose - 55 mg, modified corn starch - 20 mg, calcium stearate - 1 mg.
15 pcs. - contour cellular packaging (1) - cardboard packs.
15 pcs. - contour cell packaging (2) - cardboard packs.
pharmachologic effect
Histamine H1 receptor blocker. Prevents the development and facilitates the course of allergic reactions. It has antiallergic, antiexudative and action, preventing the development of allergic inflammation in the tissue. Weakens the effect of histamine, reduces its effect on vascular permeability (by reducing permeability, it has an anti-edematous effect), reduces its bronchospastic effect and spasmogenic effect on intestinal smooth muscles, weakens the hypotensive effect of histamine. Hifenadine reduces the content of histamine in tissues (associated with the ability to activate diamine oxidase, an enzyme that inactivates histamine). During a course of treatment, the antihistamine effect of quifenadine does not decrease. It has a moderate antiserotonin effect and exhibits weak m-anticholinergic activity. Does not have a depressing effect on the central nervous system.
Pharmacokinetics
Suction and distribution
Hifenadine is quickly absorbed from the gastrointestinal tract, absorption is 45%, and after 30 minutes it is found in body tissues. Cmax in the blood is reached after 1 hour. It has low lipophilicity and does not penetrate well through the BBB. Highest concentration active substance found in the liver, slightly less in the lungs and kidneys, the lowest in the brain (less than 0.05%, which explains the absence of a pronounced sedative and hypnotic effect).
Metabolism and excretion
Hifenadine is metabolized in the liver.
Metabolites are excreted by the kidneys and intestines. The unabsorbed portion of the drug is excreted through the intestines.
Indications
- hay fever;
- acute and chronic urticaria;
- angioedema;
- allergic rhinitis;
— dermatoses (including eczema, psoriasis);
— neurodermatitis;
- skin itching.
Contraindications
- pregnancy;
- lactation period ( breastfeeding);
- children under 3 years of age (for tablets 10 mg and 25 mg);
- children's and adolescence up to 18 years (for 50 mg tablets);
- sucrase/isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption, because the drug contains sucrose;
- hypersensitivity to the components of the drug.
Carefully The drug should be prescribed for diseases of the gastrointestinal tract, liver and kidneys.
Dosage
The drug is taken orally after meals.
The dosage regimen of the drug is the same for all indications for use. The dosage of quifenadine may be influenced by the severity of the allergic reaction, the individual sensitivity of the patient, as well as the severity of possible side effects.
For adults prescribed 50 mg 1-4 times/day or 25 mg 2-4 times/day. The maximum daily dose is 200 mg. The average course of treatment is 10-20 days. If necessary, the course of treatment is repeated.
For children aged 3 to 7 years- 10 mg 2 times/day; aged 7 to 12 years- 10-15 mg 2-3 times/day; over 12 years old- 25 mg 2-3 times/day. The course of treatment is 10-15 days.
Side effects
From the digestive system: dryness of the oral mucosa, nausea, vomiting.
From the side of the central nervous system: drowsiness, headache.
Others: allergic reactions.
Overdose
Symptoms: dry mucous membranes, headache, vomiting, and other symptoms of dyspepsia.
Treatment: gastric lavage, taking activated carbon, carrying out symptomatic therapy.
In case of overdose, the patient should consult a doctor.
Drug interactions
Hifenadine does not enhance the inhibitory effect of ethanol and hypnotics on the central nervous system.
Having weak m-anticholinergic properties, the drug can reduce gastrointestinal motility, which helps increase the absorption of slowly absorbed drugs (for example, indirect action - coumarins).
special instructions
The absence of a pronounced m-anticholinergic effect allows the drug to be prescribed to patients for whom antihistamines with m-anticholinergic activity are contraindicated.
Use in pediatrics
Many people suffer from allergies. These hypersensitive reactions of the body to various pathogens do not allow one to live in peace. This article will present one of the best solutions to the problem that anyone can use. It doesn't cost a fortune and works great 90% of the time.
Many people are interested in one question: “What are Fenkarol tablets for?” This remedy is designated by doctors as an antihistamine. That is, it reduces the amount of histamines affecting every human organ and system. Its unique description of action makes it very different from other drugs with the same mechanism.
Acting as a blocker of histamine Hi receptors inside each tissue, Fenkarol activates histaminase. Another name for it is the enzyme diamine oxidase. This is how the required level of histamine is achieved.
The effectiveness of using such a medicine for patients is difficult to overestimate, especially in cases where similar remedies have failed to cope with the task. When taken, each tablet will be quickly absorbed into the membrane. gastrointestinal tract. After half an hour, an improvement in the person’s condition is already observed. And after the same period of time, the maximum concentration in the blood is heard. This medication is metabolized only in the liver. Each metabolite is excreted through urine after two days.
Composition, active substance, release forms
There is only one active substance - quifenadine. He is the foundation. Of 100% of the substance there are 10 milligrams. The auxiliary components are water used for the injection solution, up to 1 milliliter, and glutamic acid, present in an amount of 6.26 milligrams. A solution is created in such proportions and administered intramuscularly.
The tablets are manufactured in these parameters. The active component does not change. His dose remains the same. Excipients will be the content of potato starch, the presence of sucrose, corn starch, calcium stearate. Together they should make up 100% of one tablet, minus the amount of quifenadine.
Gel and cream are dispensed in the form of a liquid, without any color and not containing anything. The tablets are white. Small cylinder shape. If the tablet has 10 mg of the active ingredient, then no special mark will be applied to it.
Dispensed only with a doctor's prescription!!!
How to take medicine for adults and children - dosage, instructions
Being decongestant, antiallergic, antipruritic, antiexudative, it is used as one of the best remedies against allergic reactions. It is the action of the active component that prevents the development and makes the course of the disease calmer. Also, when taken, a decrease in itching and inflammation in the tissues is noticed.
By making any action of histamine weaker, these products completely reduce its effect on blood vessels. They become more permeable, allowing blood to move faster.
There is also a decrease in bronchospastic effect and spasmogenic effect on intestinal smooth muscles. The hypotensive effects of histamine become less, which makes its amount in the tissues less. All enzymes that activate it completely calm down and go away.
Even long-term treatment will not reduce the effectiveness of the main element. Mild antiserotonin actions do not affect cholimone blocking activity at all. In 100% of patients, no effects or effects on the central nervous system were observed.
Before use, you need to study Fenkarol; the instructions for use describe very rapid absorption with intramuscular injection. Wherein peak value component in the blood is achieved twice as fast. Since it has low lyophilicity, it crosses the blood-brain barrier very poorly. The highest concentration is observed in the human liver. The respiratory and fluid removal systems lag far behind in this indicator. The brain will contain the least of all. Therefore, when taking it, a person does not calm down or fall asleep. Excreted through urine.
In tablet form, almost half of the active substance is absorbed very quickly inside the stomach and intestines. Only after this action does the 30-minute countdown begin so that hifenadine reaches all its tissues throughout the body. The maximum amount in the blood will be only 60 minutes after taking it. All Chemical properties the same as for injections and balm, but in this case the unabsorbed part will be excreted by the liver.
As the abstract states, in both options, adults take 50 mg per day up to four times a day. Based on this indicator, calculate everything else! Always only after eating.
There is also a weaker Fenkarol, the instructions for children are the same as for adults, but the content of active components in it and the total dosage are much less than in the adult version.
Some parents, due to poor genetics, give their children this drug from birth, sometimes using ointment. Doctors have never been able to prove a negative effect, even in the absence of symptoms. But, it is better to undergo additional consultation with a pediatrician.
Children are given when they appear:
- Manifestations of urticaria on the skin;
- Various eczemas;
- Psoriasis;
- A runny nose that begins at the first sign of an allergy.
Fenkarol for children copes well with diseases such as:
- Hay fever;
- Neurodermatitis;
- Allergy with signs of suffocation.
Tablets of 10 milligrams are given to children when they have atopic dermatitis, severe allergic swelling, severe itching on the skin, and hay fever.
Immediately before vaccinations, taking Fenkarol is prohibited in cases where allergies are at their peak. The course must be completed before vaccination begins.
The pediatrician should calculate dosage according to the patient's age. Proper treatment greatly reduces the risk of swelling or rashes. The course always consists of a two-week period. Take after meals.
Features of use during pregnancy and lactation
Reception is prohibited throughout. If a woman is at the lactation stage, then the baby will have to drink formula. If these features are violated, it is possible side effects not only in the mother, but also in the child. Namely: dry mucous membrane in the oral cavity, nausea, drowsiness, headaches.
Fenkarol's analogs
There is a fairly impressive list of similar medications to Fenkarol. Analogs even half may not have the same effect. But according to the principle of action, each substitute is similar:
- Aleric;
- Desal;
- Clarisens;
- Histaphen;
- Loratek;
- Telfast;
- Peritol.
Analogs of the drug, of course, can solve the problem, but not with the same effect. It all comes down to a strong core component.
Contraindications, side effects
In all dosage forms the use is prohibited:
- If the body completely refuses to take quifenadine. And also with strong sensitivity to others chemical elements drug.
- When a girl carries a fetus at any stage.
- DURING lactation.
- Any alcoholic drink.
With a little caution, it is possible for diseases of the digestive system, liver and kidney dysfunction.
Persons under 18 years of age are prohibited from any intravenous injections. The manual clearly describes that tablets are not given for sucrose deficiency or individual fructose intolerance in children. Their active component content should not exceed 10 mg for up to three years.
Compatibility of the drug with alcohol. Does not enhance the effects of alcoholic drinks. Careful use is possible!
Interaction with other drugs
With other sedatives they do not increase. But any combination with other drugs changes the concentration in the blood of slowly absorbing drugs. For example, coumarin. Compatible with alcohol in small doses.
Instructions for medical use of the drug
F E N K A R O L® 10 mg
Tradename
Fenkarol® 10 mg
International nonproprietary name
Hifenadine
Dosage form
Tablets 10 mg
One tablet contains
active substance - fenkarol 10 mg,
excipients - sugar, potato starch, calcium stearate.
Description
Tablets are white or almost white in color, flat-cylindrical in shape with a bevel.
Pharmacotherapeutic group
Other systemic antihistamines.
ATC code R06A X
Pharmacological properties
Pharmacokinetics
45% of fenkarol is quickly absorbed from the gastrointestinal tract and is found in the body tissues within 30 minutes. The maximum concentration of the active substance in the blood plasma is reached after an hour. The highest concentration of the active substance is observed in the liver, lungs and kidneys, the lowest in brain tissue.
Fenkarol has low lipophilicity and its content in brain tissue is low (less than 0.05%), which explains the absence of an inhibitory effect on the central nervous system. nervous system, but with individual hypersensitivity, a slight sedative effect is possible.
Fenkarol is metabolized in the liver. Metabolites and the unchanged portion of the drug are excreted mainly in urine, bile and through the lungs. The unabsorbed part of the drug is excreted through the intestines. The main part of the drug and its metabolites (about 44%) is excreted in the urine within 48 hours and another 1% over the next 48 hours.
Pharmacodynamics
Fenkarol is an antihistamine, has an antiallergic effect. It weakens the effect of histamine (reduces its bronchospastic effect, spasmogenic effect on intestinal smooth muscles, hypotensive effect, effect on vascular permeability). It not only blocks H1-histamine receptors, but also reduces the concentration of histamine in tissues, which is associated with its ability to activate diamine oxidase, an enzyme that inactivates histamine. It has a moderate antiserotonin effect and exhibits weak anticholinergic activity. Does not have a pronounced inhibitory effect on the central nervous system.
The drug has a pronounced antipruritic, desensitizing effect.
Indications for use
hay fever
food and drug allergies, other allergic diseases
acute and chronic urticaria
Quincke's edema (angioedema)
hay fever
allergic rhinitis
dermatoses (eczema, neurodermatitis, itchy skin)
non-infectious allergic reactions with a bronchospastic component.
Directions for use and doses
Fenkarol is taken orally immediately after meals.
Children from 6 to 7 years old - 10 mg 2 times a day; from 7 to 12 years - 10-15 mg 2-3 times a day. The duration of treatment is 10-12 days. If necessary, the course is repeated. Children over 12 years old - take Fenkarol 25, 25 mg tablets 2-3 times a day.
If the next dose is not taken on time, continue taking the drug without increasing the dose. If necessary, consult a doctor.
Side effects
dryness of the mucous membranes of the oral cavity
dyspeptic symptoms (nausea, vomiting)
drowsiness
Side effects usually go away by reducing the dose or discontinuing the drug. The likelihood of side effects increases with diseases of the gastrointestinal tract.
If there are side effects, especially those that are not listed in the instructions, you should consult a doctor.
Contraindications
hypersensitivity to fenkarol or auxiliary components of the drug.
Children under 6 years old
Drug interactions
Fenkarol does not enhance the inhibitory effect of hypnotics on the central nervous system. Fenkarol has weak M-anticholinergic properties, but with a decrease in gastrointestinal motility, the absorption of slowly absorbed medications may increase (for example, indirect anticoagulants - coumarins).
special instructions
Use caution in case of severe diseases of the cardiovascular system, gastrointestinal tract and kidneys.
Pregnancy and lactation
Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms
Overdose
Symptoms: dry mucous membranes, headache, vomiting, epigastric pain and other dyspeptic symptoms.
Treatment: symptomatic therapy is carried out. There is no special antidote.
Release form and packaging
10 tablets each in a blister pack made of polyvinyl chloride film and aluminum foil.
2 contour packages together with instructions for medical use in the state and Russian languages are placed in a cardboard box.
Storage conditions
Store in a dry place, protected from light, at a temperature not exceeding
25°C.
Keep out of the reach of children!
Shelf life
The drug should not be used after the expiration date.
Conditions for dispensing from pharmacies
On prescription
manufacturer
JSC “Olainfarm”, Latvia
Address: st. Rupnicu 5, Olaine, LV - 2114, Latvia
Registration Certificate Holder
JSC “Olainfarm”, Latvia
Address of the organization that accepts claims from consumers regarding product quality on the territory of the Republic of Kazakhstan:
050009 Almaty, Abay Ave. 151/115, office 807,
phone/fax 007 727 333 46 52,
Registration number: LP 002387-270214
Trade name of the drug: Fenkarol.
International nonproprietary name: hifenadine.
Dosage form: solution for intramuscular administration.
Composition per 1 ml of finished product:
Active substance: hifenadine (fenkarol base), calculated as 100% substance 10.00 mg;
Excipients: glutamic acid 6.26 mg, water for injection up to 1.0 ml.
Description: transparent colorless liquid.
Pharmacotherapeutic group: antiallergic agent - H1-histamine receptor blocker.
ATX code
Pharmacological properties
Pharmacodynamics
The active ingredient of the drug hifenadine is a blocker of H1-histamine receptors, prevents the development and facilitates the course of allergic reactions. It has antiallergic, antiexudative and antipruritic effects, preventing the development of allergic inflammation in the tissue. Weakens the effect of histamine, reduces its effect on vascular permeability (by reducing permeability, it has an anti-edematous effect), reduces its bronchospastic effect and spasmogenic effect on intestinal smooth muscles, weakens the hypotensive effect of histamine. Hifenadine reduces the content of histamine in tissues (associated with the ability to activate diamine oxidase, an enzyme that inactivates histamine). During a course of treatment, the antihistamine effect of quifenadine does not decrease. It has a moderate antiserotonin effect and exhibits weak m-anticholinergic activity. Does not have a depressing effect on the central nervous system.
Pharmacokinetics
After intramuscular (IM) administration, the solution is rapidly absorbed and the maximum concentration of quifenadine in the blood plasma is achieved after 30 minutes. Hifenadine has low lipophilicity and does not penetrate the blood-brain barrier well. The highest content of the active substance was observed in the liver, somewhat less in the lungs and kidneys, the lowest in the brain (less than 0.05%, which explains the absence of a pronounced sedative and hypnotic effect). The drug is metabolized in the liver, forming inactive metabolites, which are excreted primarily by the kidneys.
Indications for use
Hay fever, urticaria, angioedema (Quincke's edema) in case of severe disease and the need for intramuscular use of antihistamines.
Contraindications
Individual intolerance to quifenadine.
Hypersensitivity to any of the components of the drug.
Children under 18 years of age.
Pregnancy and breastfeeding period.
Carefully for decompensated diseases of cardio-vascular system, gastrointestinal tract, liver and kidneys.
Use during pregnancy and breastfeeding
Directions for use and doses
Intramuscularly. Subcutaneous administration is not used due to irritation.
Hay fever
2 ml (20 mg) 2 times a day for 3 days, then 2 ml (20 mg) 1 time a day for 2 days. The total duration of treatment is 5 days.
Urticaria and angioedema (Quincke's edema)
2 ml (20 mg) 2 times a day for 5 days, then 2 ml (20 mg) 1 time a day for 3 days. The total duration of treatment is 8 days.
The maximum single dose is 20 mg; the maximum daily dose is 40 mg.
After relief of acute allergic reactions, it is recommended to switch to the use of the drug Fenkarol in tablet form.
Side effect
The drug is well tolerated. Rarely possible adverse reactions: dryness of the oral mucosa, nausea, vomiting, drowsiness, allergic reactions, headache.
Overdose
Symptoms: dry mucous membranes, headache, vomiting, abdominal pain and other dyspeptic symptoms. Treatment is symptomatic. It is necessary to take activated carbon and consult a doctor immediately.
Interaction with other drugs
Does not enhance the inhibitory effect of alcohol and hypnotics on the central nervous system. Possessing weak M-anticholinergic properties, it can reduce gastrointestinal motility and increase the absorption of slowly absorbed medicines(for example, indirect anticoagulants - coumarin derivatives).
special instructions
The absence of a pronounced anticholinergic effect makes it possible to prescribe antihistamines with anticholinergic activity to patients who are contraindicated.
Impact on the ability to drive vehicles and maintain potentially dangerous mechanisms
Persons whose profession requires increased concentration and speed of psychomotor reactions should first determine (by short-term prescription) whether the drug has a sedative effect.
Release form
Solution for intramuscular administration 10 mg/ml.
1 ml or 2 ml of the drug in neutral glass ampoules.
10 ampoules are placed in a blister pack made of transparent polyvinyl chloride film. 1 blister pack along with instructions for use is placed in cardboard packs.
Instructions for medical use of the drug
Fenkarol® 25 mg
Tradename
Fenkarol® 25 mg
International nonproprietary name
Hifenadine
Dosage form
Pills
One tablet contains
active substance - fenkarol (hifenadine hydrochloride) 25 mg,
excipients - potato starch, sugar, calcium stearate.
Description
White or almost white tablets, flat-cylindrical in shape with a bevel
Pharmacotherapeutic group
Systemic antihistamines
Other systemic antihistamines
ATX code R06AX
Pharmacological properties
Pharmacokinetics
45% of fenkarol is quickly absorbed from the gastrointestinal tract and is found in the body tissues within 30 minutes. The maximum concentration of the active substance in the blood plasma is achieved after an hour. The highest concentration of the active substance is observed in the liver, lungs and kidneys, the lowest in brain tissue. Hifenadine has low lipophilicity and its content in brain tissue is low (less than 0.05%), which explains the lack of an inhibitory effect on the central nervous system, but with individual hypersensitivity, a weak sedative effect is possible.
Hifenadine is metabolized in the liver. Metabolites and the unchanged portion of the drug are excreted mainly in the urine, bile and through the lungs. The unabsorbed part of the drug is excreted through the intestines. The main part of the drug and its metabolites (about 44%) is excreted in the urine within 48 hours and another 1% over the next 48 hours.
Pharmacodynamics
Fenkarol is an antihistamine (quinuclidylcarbinol derivative) that reduces the effect of histamine on organs and their systems. Fenkarol blocks histamine H1 receptors in peripheral tissues and also activates the enzyme diamine oxidase (histaminase), thus reducing the content of histamine in tissues. This explains the effectiveness of fenkarol for patients whose treatment with other antihistamines is ineffective. Fenkarol has low lipophilicity, therefore it penetrates poorly through the blood-brain barrier, has little effect on the processes of serotonin deamination in brain tissue and on the activity of monoamine oxidase enzymes.
Fenkarol reduces the toxic effect of histamine, eliminates or weakens the bronchoconstrictor effect and spasmodic effect on intestinal smooth muscles, weakens the hypotensive effect of histamine and its effect on capillary permeability. Fenkarol has a moderate antiserotonin and weak anticholinergic effect, and does not have an adrenolytic effect.
The drug has a pronounced antipruritic, desensitizing, and also moderate diuretic effect.
Indications for use
hay fever
food and drug allergies, other allergic diseases
acute and chronic urticaria
Quincke's edema (angioedema)
hay fever
allergic rhinitis
dermatoses (eczema, neurodermatitis, itchy skin)
non-infectious allergic reactions with a bronchospastic component
Directions for use and doses
Fenkarol is taken orally immediately after meals.
Dose for adults: 25-50 mg 3-4 times a day. The maximum daily dose is 200 mg. Duration of treatment is 10-20 days. If necessary, the course is repeated.
Children over 12 years old - 25 mg 2-3 times a day. The duration of treatment is 10-15 days. If necessary, the course is repeated.
If the next dose is not taken on time, continue taking the drug without increasing the dose. If necessary, consult a doctor.
Side effects
dryness of the mucous membranes of the oral cavity
dyspeptic symptoms (nausea, vomiting)
sedative effect.
Side effects usually go away by reducing the dose or discontinuing the drug.
The likelihood of side effects increases with diseases of the gastrointestinal tract.
If side effects occur, especially those that are not listed in the instructions, you should consult a doctor.
Contraindications
hypersensitivity to fenkarol or auxiliary components of the drug
Children's age up to 12 years
First trimester of pregnancy and lactation period
Drug interactions
Fenkarol does not enhance the inhibitory effect of hypnotics on the central nervous system. Fenkarol has weak M-anticholinergic properties, but with a decrease in gastrointestinal motility, the absorption of slowly absorbed medications may increase (for example, indirect anticoagulants - coumarins).
special instructions
Use caution in case of severe diseases of the cardiovascular system, gastrointestinal tract or liver, kidneys.
Use in pediatrics
In pediatric practice, tablets Fenkarol® 10 mg and dosed powder Fenkarol® 10 mg are used.
Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms
People whose work requires a quick physical or psychomotor reaction (transport drivers, etc.) should first determine (by short-term administration) whether the drug has a sedative effect. Caution must be exercised during the period of use of the drug.
Overdose
Symptoms: dry mucous membranes, headache, vomiting, epigastric pain and other dyspeptic symptoms.
Treatment: symptomatic therapy. There is no specific antidote.
Release form and packaging
10 tablets are placed in a contour cell packaging made of polyvinyl chloride film and printed aluminum foil.
2 contour packages together with instructions for medical use in the state and Russian languages are placed in a cardboard box.
Storage conditions
Store in a dry place, protected from light, at a temperature not exceeding 25 ° C.
Keep out of the reach of children!
Shelf life
Do not use after expiration date.
Conditions for dispensing from pharmacies
On prescription
manufacturer
JSC "Olainfarm"
Address: st. Rupnitsa 5, Olaine, LV - 2114, Latvia.
Registration Certificate Holder
JSC "Olainfarm"
Address: st. Rupnitsa 5, Olaine, LV - 2114, Latvia.
Address of the organization receiving claims from consumers regarding product quality in the territory of the Republic of Kazakhstan:
050009 Almaty, Abay Ave. 151/115, office 807,
phone/fax 007 727 333 46 52,
